Effects of Hepatic Impairment on the Pharmacokinetic Profile and Safety of Lobeglitazone
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1045
Abstract: In this open‐label, single‐dose, parallel‐group study, we compared the pharmacokinetic profile and safety of lobeglitazone, a thiazolidinedione acting as an agonist for peroxisome proliferator‐activated receptors, in patients with hepatic impairment (HI) and healthy matched controls… read more here.
Keywords: profile safety; safety lobeglitazone; lobeglitazone; pharmacokinetic profile ... See more keywords
Pharmacokinetic Interactions Between Gemigliptin and Metformin, and Potential Differences in the Pharmacokinetic Profile of Gemigliptin Between the Mexican and Korean Populations: A Randomized, Open-label Study in Healthy Mexican Volunteers.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.08.015
Abstract: PURPOSE The aim of this study was to assess the pharmacokinetic interactions between a newly developed dipeptidyl peptidase (DPP)-4 inhibitor, gemigliptin, and metformin in healthy Mexican male volunteers, and the differences in the pharmacokinetic profile… read more here.
Keywords: gemigliptin metformin; pharmacokinetic profile; gemigliptin; profile gemigliptin ... See more keywords
Pharmacokinetic profile and oral bioavailability of Kaurenoic acid from Copaifera spp. in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Fitoterapia"
DOI: 10.1016/j.fitote.2018.05.013
Abstract: Kaurenoic acid (KA) is a kaurane diterpene found in several medicinal plants that displays biological activities, such as anti-inflammatory, smooth muscle relaxant and hypotensive response. However, there are no pharmacokinetic data available about this molecule.… read more here.
Keywords: oral bioavailability; bioavailability; pharmacokinetic profile; profile oral ... See more keywords
Pharmacokinetic Profile of Twice- and Once-daily Tacrolimus in Pediatric Kidney Transplant Recipients.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2016.11.022
Abstract: BACKGROUND The aim of this study was to assess the differences in pharmacokinetic (PK) profiles after the 1:1 ratio-based conversion from a twice-daily to a once-daily tacrolimus formulation (TD-TAC and OD-TAC, respectively) in pediatric recipients… read more here.
Keywords: tac; daily tacrolimus; tac tac; twice daily ... See more keywords
2-Deoxyglycoside conjugates of lupane triterpenoids with high cytotoxic activity - synthesis, activity, and pharmacokinetic profile.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00565
Abstract: A set of 41 glycosidic conjugates of pentacyclic triterpenes was synthesized in order to improve the solubility of highly cytotoxic parent compounds. Their in vitro cytotoxic activity was evaluated in 25 cancer cell lines and… read more here.
Keywords: ccrf cem; pharmacokinetic profile; compound; activity ... See more keywords
Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01264
Abstract: PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties: potency,… read more here.
Keywords: pharmacokinetic profile; pi3k inhibitor; profile; efficacy ... See more keywords
Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01349
Abstract: In this study, we have designed and synthesized pyrazoline analogues that partially mimic the structure of mycobactin, to address the requirement of novel therapeutics to tackle the emerging global challenge of antimicrobial resistance (AMR). Our… read more here.
Keywords: pump inhibition; pharmacokinetic profile; efflux pump; mycobactin ... See more keywords
Cremophor EL Alters the Plasma Protein Binding and Pharmacokinetic Profile of Valspodar in Rats.
Sign Up to like & getrecommendations! Published in 2017 at "Drug research"
DOI: 10.1055/s-0043-111411
Abstract: Cremophor EL is a nonionic surfactant widely used in pharmaceutical formulations. Nonetheless, there are several reports on the influence of this excipient on the protein binding, pharmacokinetics, and pharmacodynamics of drugs. Valspodar is an investigational… read more here.
Keywords: valspodar; protein binding; plasma protein; formulation ... See more keywords
Pharmacokinetic Profile of Δ9-tetrahydrocannabinol, Cannabidiol and Metabolites in Blood following Vaporization and Oral Ingestion of Cannabidiol Products.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkab124
Abstract: There is limited data on the comparative pharmacokinetics of cannabidiol (CBD) across oral and vaporized formulations. This within-subject, double-blind, double-dummy, placebo-controlled laboratory study analyzed the pharmacokinetic profile of CBD, Δ9-tetrahydrocannabinol (∆9-THC) and related metabolites in… read more here.
Keywords: pharmacokinetic profile; cannabidiol; vaporized cbd; cbd ... See more keywords
Tolerability and pharmacokinetic profile of a novel benzene‐poly‐carboxylic acids complex with cis‐diammineplatinum (II) dichloride in dogs with malignant mammary tumours
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary and Comparative Oncology"
DOI: 10.1111/vco.12144
Abstract: The pharmacokinetic profile, tolerability and efficacy of benzene-poly-carboxylic acids complex with cis-diammineplatinum (II) dichloride (BP-C1) were studied in dogs with mammary cancer. A three-level response surface pathway designed trial was performed on seven dogs. At… read more here.
Keywords: acids complex; carboxylic acids; pharmacokinetic profile; benzene poly ... See more keywords
Lomustine Incorporated Lipid Nanostructures Demonstrated Preferential Anticancer Properties in C6 Glioma Cell Lines with Enhanced Pharmacokinetic Profile in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2021.6977
Abstract: Effective treatment of glioma still stands as a challenge in medical science. The work aims for the fabrication and evaluation of lipid based nanostructures for improved delivery of lomustine to brain tumor cells. Experimental formulations… read more here.
Keywords: glioma cell; drug; lomustine incorporated; profile ... See more keywords