Bioequivalence and Pharmacokinetic Profiles of 2 Trimetazidine Modified‐release Tablets Under Fasting and Fed Conditions in Chinese Healthy Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1200
Abstract: This study aims to assess the bioequivalence of test and reference formulations of trimetazidine dihydrochloride in healthy Chinese volunteers under fasting and fed conditions, and to determine the effect of food on the pharmacokinetic profiles… read more here.
Keywords: fasting fed; fed conditions; profiles trimetazidine; bioequivalence ... See more keywords
Single‐ and Multiple‐Dose Safety, Tolerability, and Pharmacokinetic Profiles of ASP8062: Results From 2 Phase 1 Studies
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.766
Abstract: ASP8062 is an orally active γ‐amino‐butyric acid type B (GABAB) receptor positive allosteric modulator currently in phase 2 development. Safety and pharmacokinetic (PK) profiles of ASP8062 were evaluated in 2 studies in healthy subjects. The… read more here.
Keywords: profiles asp8062; pharmacokinetic profiles; safety; single multiple ... See more keywords
Pharmacokinetic profiles of a SARS‐COV‐2 neutralizing antibody BD‐604 in cynomolgus monkeys
Sign Up to like & getrecommendations! Published in 2021 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3122
Abstract: Abstract Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) has spread worldwide as a severe pandemic and effective therapeutic medications are urgently needed. As reported previously, BD‐604 is a fully human monoclonal antibody with… read more here.
Keywords: 604 cynomolgus; cynomolgus monkeys; pharmacokinetic profiles; antibody ... See more keywords
Comparison of Pharmacokinetic Profiles of Beraprost Sustained Release in Japanese, Chinese, and Korean Healthy Adult Males
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DOI: 10.1007/s40261-021-01031-8
Abstract: Beraprost sodium (BPS), an orally administrable prostaglandin I2 derivative, is used for the treatment of chronic arterial occlusion and pulmonary arterial hypertension and has potential efficacy in nephropathy. Beraprost sustained release (beraprost SR) is an… read more here.
Keywords: japanese chinese; pharmacokinetic profiles; chinese korean; sustained release ... See more keywords
Pharmacokinetic profiles of the active metamizole metabolites in healthy horses
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Veterinary Pharmacology and Therapeutics"
DOI: 10.1111/jvp.12342
Abstract: Metamizole (MT) is an analgesic and antipyretic drug labelled for use in humans, horses, cattle, swine and dogs. MT is rapidly hydrolysed to the active primary metabolite 4-methylaminoantipyrine (MAA). MAA is formed in much larger… read more here.
Keywords: healthy horses; pharmacokinetic profiles; plasma concentrations; metamizole metabolites ... See more keywords
Pharmacokinetic profiles of meloxicam after single IV and PO administration in Bilgorajska geese.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12817
Abstract: The purpose of this study was two-fold: I) to determine the pharmacokinetic profile of meloxicam (MLX) in geese after intravenous (IV) and oral (PO) administration and II) to assess tissue residues in muscle, heart, liver,… read more here.
Keywords: administration; pharmacokinetic profiles; tissue; profiles meloxicam ... See more keywords
No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug metabolism"
DOI: 10.2174/1389200223666220215151945
Abstract: BACKGROUND Significant inter-subject variability in pharmacokinetics and clinical outcomes has been observed for the antimalarial agent piperaquine (PQ). PQ is metabolized by CYP3A4, mainly regulated by pregnane X receptor (PXR). CYP3A4(*1B) polymorphism did not affect… read more here.
Keywords: 8055c polymorphism; pxr 8055c; effect pxr; pharmacokinetic profiles ... See more keywords
IN SILICO STUDIES ON DIACYL DERIVATIVES OF PHLOROGLUCINOL TO ENHANCE PHARMACODYNAMIC AND PHARMACOKINETIC PROFILES OF 2,4,6-TRIHYDROXY-3-GERANYL-ACETOPHENONE
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DOI: 10.22159/ijap.2021v13i2.40784
Abstract: Objective: The purpose of this study was to evaluate the LOX inhibitory activity, and predict the drug likeness properties of designed diacyl derivatives of phloroglucinol, using in silico method. Methods: The designed derivatives were subjected… read more here.
Keywords: diacyl derivatives; pharmacodynamic pharmacokinetic; derivatives phloroglucinol; study ... See more keywords
Determination and Pharmacokinetic Profiles of Four Active Components From Scrophularia ningpoensis Hemsl. in Rats
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DOI: 10.3389/fphar.2020.612534
Abstract: Acteoside, angoroside C, harpagoside, and cinnamic acid, which are the main bioactive ingredients of Scrophularia ningpoensis Hemsl., have wide clinical use with various biological effects. A new and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)… read more here.
Keywords: active components; pharmacokinetic profiles; four active; ningpoensis hemsl ... See more keywords
ADME, Pharmacokinetic Scaling, Pharmacodynamic and Prediction of Human Dose and Regimen of Novel Antiviral Drugs
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DOI: 10.3390/pharmaceutics15041212
Abstract: The search for new drugs is an extremely time-consuming and expensive endeavour. Much of that time and money go into generating predictive human pharmacokinetic profiles from preclinical efficacy and safety animal data. These pharmacokinetic profiles… read more here.
Keywords: pharmacodynamic prediction; pharmacokinetic scaling; prediction human; adme pharmacokinetic ... See more keywords