Pharmacokinetic properties of 4-fluoroamphetamine in serum and oral fluid after oral ingestion.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2595
Abstract: INTRODUCTION Each year, synthetic drugs occur in high numbers on the illicit drug market. But data on their pharmacology and toxicology are scarce. Therefore, a controlled study was performed to evaluate pharmacokinetic parameters of 4-fluoroamphetamine… read more here.
Keywords: pharmacokinetic properties; oral fluid; fluoroamphetamine serum; fluid ... See more keywords
Molecular mechanism of action and pharmacokinetic properties of methotrexate
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05481-9
Abstract: Since its discovery in 1945, methotrexate has become a standard therapy for number of diseases, including oncological, inflammatory and pulmonary ones. Major physiological interactions of methotrexate include folate pathway, adenosine, prostaglandins, leukotrienes and cytokines. Methotrexate… read more here.
Keywords: pharmacokinetic properties; methotrexate; molecular mechanism; therapy ... See more keywords
The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.08.098
Abstract: A liquid crystalline (LC) system, composed of phosphatidylcholine, sorbitan monoleate, and tocopherol acetate, was investigated to understand the in vivo transformation after subcutaneous injection, coupled with the physicochemical and pharmacokinetic properties of the formulation. The… read more here.
Keywords: pharmacokinetic properties; system; transformation; properties liquid ... See more keywords
Improving the Imaging Contrast of 68Ga-PSMA-11 by Targeted Linker Design: Charged Spacer Moieties Enhance the Pharmacokinetic Properties.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00458
Abstract: 68Ga-Glu-urea-Lys-(Ahx)-HBED-CC (68Ga-PSMA-11) represents a successful radiopharmaceutical for PET/CT imaging of prostate cancer. Further optimization of the tumor-to-background contrast might significantly enhance the sensitivity of PET/CT imaging and the probability of detecting recurrent prostate cancer at… read more here.
Keywords: pharmacokinetic properties; contrast; 68ga psma; linker ... See more keywords
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01774
Abstract: PEGylation of therapeutic agents is known to improve the pharmacokinetic behavior of macromolecular drugs and nanoparticles. In this work, we performed the conjugation of polyethylene glycols (220-5000 Da) to a series of non-steroidal small agonists… read more here.
Keywords: pharmacokinetic properties; properties relationships; receptor; structure properties ... See more keywords
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00172
Abstract: The DNA-PK complex is activated by double-strand DNA breaks and regulates the non-homologous end-joining repair pathway; thus, targeting DNA-PK by inhibiting the DNA-PK catalytic subunit (DNA-PKcs) is potentially a useful therapeutic approach for oncology. A… read more here.
Keywords: pharmacokinetic properties; dna; herg activity; optimization herg ... See more keywords
Investigation of the pharmacokinetic properties of synthetic heparan sulfate oligosaccharides.
Sign Up to like & getrecommendations! Published in 2022 at "Glycobiology"
DOI: 10.1093/glycob/cwac068
Abstract: Heparan sulfate (HS) is a sulfated polysaccharide with a wide range of biological activities. There is increasing interest in the development of structurally homogeneous HS oligosaccharides as therapeutics. However, the factors influencing the pharmacokinetic properties… read more here.
Keywords: clearance; heparan sulfate; mer; pharmacokinetic properties ... See more keywords
Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain
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DOI: 10.1097/aln.0000000000002145
Abstract: Background: Desirable product attributes for treatment of moderate-to-severe acute pain in many medically supervised settings are rapid onset and a route of administration not requiring intravenous access. The pharmacokinetic characteristics of sublingually administered tablets containing… read more here.
Keywords: acute pain; pharmacokinetic properties; sublingual tablet;
Rivaraoxaban dosing is based on more than just pharmacokinetic properties
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DOI: 10.1136/bmj.j608
Abstract: We at Bayer think that Moore’s letter on rivaroxaban is misleading.1 Pharmacokinetic properties are not the sole determinants of the appropriate dosing regimen, and the pharmacodynamic effect of rivaroxaban once daily is evident for the… read more here.
Keywords: pharmacokinetic properties; based pharmacokinetic; dosing based; rivaraoxaban dosing ... See more keywords
The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers [Erratum]
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s236661
Abstract: [This corrects the article DOI: 10.2147/DDDT.S215316.]. read more here.
Keywords: pharmacokinetic properties; effect food; bioequivalence two; food pharmacokinetic ... See more keywords
Radical Scavenging Activity and Pharmacokinetic Properties of Coumarin–Hydroxybenzohydrazide Hybrids
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010490
Abstract: Free radicals often interact with vital proteins, violating their structure and inhibiting their activity. In previous studies, synthesis, characterisation, and the antioxidative properties of the five different coumarin derivatives have been investigated. In the tests… read more here.
Keywords: activity pharmacokinetic; pharmacokinetic properties; scavenging activity; investigated found ... See more keywords