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Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000835
Abstract: The aim of this study is to establish a reliable LC-MS method to simultaneously quantitate raloxifene, and its major metabolites, raloxifene-6-glucuronide, raloxifene-4'-glucuronide and raloxifene-6-sulfate in rat plasma samples for pharmacokinetic studies. The separation of the…
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Keywords:
pharmacokinetic studies;
glucuronide raloxifene;
method;
raloxifene glucuronide ... See more keywords
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Published in 2022 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-022-01390-y
Abstract: Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types.…
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Keywords:
tool;
pharmacokinetic studies;
critical appraisal;
quality ... See more keywords
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Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.086
Abstract: Gut microbiome evidenced as the assembling mode of action facilitates the relationship of environmental factors (such as diet and lifestyle) with colorectal cancer. The cytotoxic and anticancer studies of the enzymatically extracted polysaccharides from selected…
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Keywords:
synbiotic candy;
cytotoxic pharmacokinetic;
pharmacokinetic studies;
studies indian ... See more keywords
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Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.10.043
Abstract: HighlightsA sensitive and rapid LC–MS/MS method for afatinib, with afatinib dimaleate as a standard.Discussed the stability of afatinib in blood in vitro.Development and pharmacokinetic studies for afatinib liposomes. Abstract A sensitive quantitative liquid chromatography‐tandem mass…
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Keywords:
rat plasma;
plasma;
pharmacokinetic studies;
afatinib liposomes ... See more keywords
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Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113019
Abstract: Corynantheidine, a minor alkaloid found in Mitragyna speciosa (Korth.) Havil, has been shown to bind to opioid receptors and act as a functional opioid antagonist, but its unique contribution to the overall properties of kratom…
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Keywords:
corynantheidine;
method development;
pharmacokinetic studies;
analysis ... See more keywords
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Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.11.081
Abstract: Abstract In the current study, simvastatin-loaded PLGA submicron particles (SIM SP) were prepared by the spray drying method. Different parameters of the nanospray drying method, such as the inlet temperature, spray mesh diameter, the spray…
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Keywords:
pharmacokinetic studies;
treatment;
drug;
submicron particles ... See more keywords
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Published in 2020 at "Seminars in perinatology"
DOI: 10.1016/j.semperi.2020.151227
Abstract: The effects of the many biochemical and physiologic changes of pregnancy on the dose-response relationship of drugs administered to pregnant women are poorly understood. The dose-response relationship is affected by pharmacokinetics, or what the body…
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Keywords:
dose response;
studies pregnancy;
pharmacokinetic studies;
drug ... See more keywords
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Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2119900
Abstract: Abstract Although liquid chromatography-tandem mass spectrometry is the gold standard analytical platform for the quantification of drugs, metabolites, and biomarkers in biological samples, it cannot localise them in target tissues. The localisation and quantification of…
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Keywords:
spectrometry imaging;
mass spectrometry;
pharmacokinetic studies;
spectrometry ... See more keywords
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Published in 2022 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004115
Abstract: A clinical review is presented of basic allometric scaling theory and its application to pharmacokinetic models in anesthesia and other fields in the biologic sciences.
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Keywords:
pharmacokinetic studies;
studies anesthesiology;
anesthesiology allometric;
scaling pharmacokinetic ... See more keywords
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Published in 2017 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000513
Abstract: The US Food and Drug Administration (FDA) issued a guidance document in 2010 on pharmacokinetic (PK) studies in renal impairment (RI) on the basis of observations that substances such as uremic toxins might result in…
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Keywords:
pharmacokinetic studies;
survey;
drug;
renal impairment ... See more keywords
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Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13305
Abstract: Pharmacokinetics is the cornerstone of understanding drug absorption, distribution, metabolism, and elimination. It is also the key to describing variability in drug response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney and liver function, etc.…
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Keywords:
pharmacokinetic studies;
reporting clinical;
statistical analysis;
drug ... See more keywords