Development and validation of ultra-high-performance liquid chromatography-MS method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000835
Abstract: The aim of this study is to establish a reliable LC-MS method to simultaneously quantitate raloxifene, and its major metabolites, raloxifene-6-glucuronide, raloxifene-4'-glucuronide and raloxifene-6-sulfate in rat plasma samples for pharmacokinetic studies. The separation of the… read more here.
Keywords: pharmacokinetic studies; glucuronide raloxifene; method; raloxifene glucuronide ... See more keywords
The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-022-01390-y
Abstract: Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types.… read more here.
Keywords: tool; pharmacokinetic studies; critical appraisal; quality ... See more keywords
Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.086
Abstract: Gut microbiome evidenced as the assembling mode of action facilitates the relationship of environmental factors (such as diet and lifestyle) with colorectal cancer. The cytotoxic and anticancer studies of the enzymatically extracted polysaccharides from selected… read more here.
Keywords: synbiotic candy; cytotoxic pharmacokinetic; pharmacokinetic studies; studies indian ... See more keywords
Determination of tyrosine kinase inhibitor afatinib in rat plasma using LC–MS/MS and its application to in vivo pharmacokinetic studies of afatinib liposomes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.10.043
Abstract: HighlightsA sensitive and rapid LC–MS/MS method for afatinib, with afatinib dimaleate as a standard.Discussed the stability of afatinib in blood in vitro.Development and pharmacokinetic studies for afatinib liposomes. Abstract A sensitive quantitative liquid chromatography‐tandem mass… read more here.
Keywords: rat plasma; plasma; pharmacokinetic studies; afatinib liposomes ... See more keywords
Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113019
Abstract: Corynantheidine, a minor alkaloid found in Mitragyna speciosa (Korth.) Havil, has been shown to bind to opioid receptors and act as a functional opioid antagonist, but its unique contribution to the overall properties of kratom… read more here.
Keywords: corynantheidine; method development; pharmacokinetic studies; analysis ... See more keywords
Preparation, evaluation and pharmacokinetic studies of spray dried PLGA polymeric submicron particles of simvastatin for the effective treatment of breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.11.081
Abstract: Abstract In the current study, simvastatin-loaded PLGA submicron particles (SIM SP) were prepared by the spray drying method. Different parameters of the nanospray drying method, such as the inlet temperature, spray mesh diameter, the spray… read more here.
Keywords: pharmacokinetic studies; treatment; drug; submicron particles ... See more keywords
Pharmacokinetic studies in pregnancy.
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DOI: 10.1016/j.semperi.2020.151227
Abstract: The effects of the many biochemical and physiologic changes of pregnancy on the dose-response relationship of drugs administered to pregnant women are poorly understood. The dose-response relationship is affected by pharmacokinetics, or what the body… read more here.
Keywords: dose response; studies pregnancy; pharmacokinetic studies; drug ... See more keywords
Potential application of mass spectrometry imaging in pharmacokinetic studies
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2119900
Abstract: Abstract Although liquid chromatography-tandem mass spectrometry is the gold standard analytical platform for the quantification of drugs, metabolites, and biomarkers in biological samples, it cannot localise them in target tissues. The localisation and quantification of… read more here.
Keywords: spectrometry imaging; mass spectrometry; pharmacokinetic studies; spectrometry ... See more keywords
Allometric Scaling in Pharmacokinetic Studies in Anesthesiology.
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DOI: 10.1097/aln.0000000000004115
Abstract: A clinical review is presented of basic allometric scaling theory and its application to pharmacokinetic models in anesthesia and other fields in the biologic sciences. read more here.
Keywords: pharmacokinetic studies; studies anesthesiology; anesthesiology allometric; scaling pharmacokinetic ... See more keywords
A survey of renal impairment pharmacokinetic studies for new oncology drug approvals in the USA from 2010 to early 2015: a focus on development strategies and future directions
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DOI: 10.1097/cad.0000000000000513
Abstract: The US Food and Drug Administration (FDA) issued a guidance document in 2010 on pharmacokinetic (PK) studies in renal impairment (RI) on the basis of observations that substances such as uremic toxins might result in… read more here.
Keywords: pharmacokinetic studies; survey; drug; renal impairment ... See more keywords
Tutorial: Statistical analysis and reporting of clinical pharmacokinetic studies
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13305
Abstract: Pharmacokinetics is the cornerstone of understanding drug absorption, distribution, metabolism, and elimination. It is also the key to describing variability in drug response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney and liver function, etc.… read more here.
Keywords: pharmacokinetic studies; reporting clinical; statistical analysis; drug ... See more keywords