Comparative pharmacodynamic and pharmacokinetic study of MIDD0301 and its (S) enantiomer
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21926
Abstract: MIDD0301 is being developed as an oral drug to relax airway smooth muscle (ASM) and reduce lung inflammation in asthma. We report a comparative study of MIDD0301 and its S isomer (MIDD0301S), and found that… read more here.
Keywords: pharmacokinetic study; comparative pharmacodynamic; pharmacodynamic pharmacokinetic; midd0301 ... See more keywords
A single LC‐MS/MS validated method for tulathromycin quantification in plasma, seminal plasma, and urine to be applied in a pharmacokinetic study in bull
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3270
Abstract: Abstract Tulathromycin is a macrolide antibiotic generally used for the treatment of respiratory diseases in cattle and swine. This work proposes an improvement of a previously published LC‐MS/MS method for tulathromycin determination in pig serum,… read more here.
Keywords: pharmacokinetic study; plasma seminal; method tulathromycin; plasma urine ... See more keywords
A validated Ultra HPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202001023
Abstract: TQ-B3203 is a new topoisomerase I inhibitor derived from camptothecin. In this paper, a simple and reliable ultra high performance liquid chromatography-tandem mass spectrometric method was developed and validated for determination of TQ-B3203 in human… read more here.
Keywords: plasma; b3203 human; human plasma; determination b3203 ... See more keywords
Simultaneous determination and pharmacokinetic study of four phenolic acids in rat plasma using UFLC–MS/MS after intravenous administration of salvianolic acid for injection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.10.017
Abstract: HIGHLIGHTSDevelopment of a sensitive and selective ultra‐fast liquid chromatography‐tandem mass spectrometry (UFLC–MS/MS) method.Application of UFLC–MS/MS for the determination of RA, sal D, LA and sal B in SAFI in rat plasma.The first pharmacokinetic study of… read more here.
Keywords: rat plasma; salvianolic acid; acid injection; acid ... See more keywords
An HPLC–MS/MS method for quantitation of Gly‐MCA in mouse plasma: Application to a pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.07.020
Abstract: HIGHLIGHTSFirst method for determination of glycine‐&bgr;‐muricholic acid (Gly‐MCA) in mice plasma by HPLC–MS/MS.This HPLC–MS/MS method is simple, rapid and sensitive, with 5.0 min runtime per sample.The developed method was successfully applied to the pharmacokinetic study… read more here.
Keywords: method; gly mca; hplc method; mca mouse ... See more keywords
An LC–MS/MS method for simultaneous determination of nine steroidal saponins from Paris polyphylla var. in rat plasma and its application to pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.07.052
Abstract: HighlightsAn UPLC–MS/MS method to quantify 9 saponins from Paris polyphylla was developed and validated.The sensitive and robust method was successfully used in a pharmacokinetic study in SD rats.PK profiles of the 9 major components in… read more here.
Keywords: method; polyphylla; paris polyphylla; pharmacokinetic study ... See more keywords
A high‐performance liquid chromatography‐tandem mass spectrometry method for the determination of lifrafenib, a novel RAF kinase and EGFR inhibitor, in human plasma and urine and its application in clinical pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.12.038
Abstract: &NA; Lifirafenib (BGB‐283), a dual inhibitor trageting BRAF kinase and EGFR, showed favorable efficacy and safety in treating patients with different cancer types harboring mutations in BRAF, KRAS and NRAS. In order to support the… read more here.
Keywords: clinical pharmacokinetic; plasma; pharmacokinetic study; plasma urine ... See more keywords
Determination and pharmacokinetic study of echinatin by UPLC‐MS/MS in rat plasma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.02.023
Abstract: HighlightsA UPLC‐MS/MS method for determination of echinatin (ECH) was developed and applied.The pharmacokinetic study demonstrated fast absorption and extensive distribution of ECH.Poor oral bioavailability (˜6.81%) of ECH was demonstrated. ABSTRACT Echinatin, one of the bioactive… read more here.
Keywords: rat plasma; study echinatin; pharmacokinetic study; study ... See more keywords
Simultaneous determination of bendamustine and γ-hydroxybendamustine in mice dried blood spots and its application in a mice pharmacokinetic study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.05.052
Abstract: A selective, sensitive and rapid mice dried blood spot (DBS) method has been developed and validated for the simultaneous quantification of bendamustine (BM) and γ-hydroxy-bendamustine (HBM) as per regulatory guidelines using an LC-MS/MS. Quality control,… read more here.
Keywords: study; dried blood; mice dried; pharmacokinetic study ... See more keywords
Enantioseparation and determination of alminoprofen in rat plasma and its application to a stereoselective pharmacokinetic study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113552
Abstract: An enantioselective study of alminoprofen (AMF) in rat plasma was performed by a rapid, specific and sensitive chiral liquid chromatography-tandem mass spectrometry (LCMS/MS) method. A homemade β-cyclodextrin (β-CD) derivatized based chiral column and a commercial… read more here.
Keywords: pharmacokinetic study; rat plasma; plasma; stereoselective pharmacokinetic ... See more keywords
Validated LC–MS/MS method for the determination of some prescribed CNS drugs: Application to an in vivo pharmacokinetic study of drug-herb metabolic interaction potential of khat
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.105261
Abstract: Abstract The consumption of khat (Catha edulis), a natural amphetamine-like psychostimulant plant, during co-administration of other conventional medications may alter treatment outcomes. Therefore, in this in-vivo study, we investigated the effect of concomitant co-administration of… read more here.
Keywords: pharmacokinetic study; study; drug; prescribed cns ... See more keywords