Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines.
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DOI: 10.1021/acschemneuro.1c00761
Abstract: (R,S)-Ketamine is rapidly metabolized to form a range of metabolites in vivo, including 12 unique hydroxynorketamines (HNKs) that are distinguished by a cyclohexyl ring hydroxylation at the 4, 5, or 6 position. While both (2R,6R)-… read more here.
Keywords: potency; cyclohexanone ring; hydroxynorketamine pharmacokinetics; pharmacokinetics antidepressant ... See more keywords