Topical delivery of PD‐1 inhibitors with laser‐assisted passive diffusion and active intradermal injection: Investigation of cutaneous pharmacokinetics and biodistribution patterns
Sign Up to like & getrecommendations! Published in 2021 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.23504
Abstract: Current cancer immunotherapeutic treatment with PD‐1 inhibitors is administered systemically. However, a local treatment strategy may be advantageous as it could provide targeted drug delivery as well as attenuate side effects seen with systemic treatments.… read more here.
Keywords: cutaneous pharmacokinetics; pharmacokinetics biodistribution; diffusion active; assisted passive ... See more keywords
In vivo pharmacokinetics and biodistribution of novel all-trans retinoic acid derivative-loaded, folate-modified poly (l-amino acid) micelles
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.09.007
Abstract: Abstract Folate is widely used as a target ligand for tumor cells, and poly ( l -aspartic acid)- b -poly-( l -phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study,… read more here.
Keywords: folate modified; folate; loaded folate; pharmacokinetics biodistribution ... See more keywords
Evaluation of Pharmacokinetics, Biodistribution, and Antimalarial Efficacy of Artemether-Loaded Polymeric Nanorods.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00507
Abstract: Artemether oily injection is recommended for the treatment of severe malaria by the intramuscular route. The major limitations of the artemisinin combination therapy are erratic absorption from the injection site and high dosing frequency due… read more here.
Keywords: polymeric nanorods; artemether loaded; microscopy; pharmacokinetics biodistribution ... See more keywords
Molecular Size Modulates Pharmacokinetics, Biodistribution, and Renal Deposition of the Drug Delivery Biopolymer Elastin-like Polypeptide
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DOI: 10.1038/s41598-018-24897-9
Abstract: Elastin-like polypeptides (ELP) are engineered proteins that consist of repetitions of a five amino acid motif, and their composition is easily modified to adjust their physical properties and attach therapeutics. Because of the repetitive nature… read more here.
Keywords: drug delivery; elp; elastin like; size ... See more keywords
Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
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DOI: 10.1124/dmd.121.000463
Abstract: Characterization of the pharmacokinetics and biodistribution of therapeutic proteins (TPs) is a hot topic within the pharmaceutical industry, particularly with an ever-increasing catalog of novel modality TPs. Here, we review the current practices, and provide… read more here.
Keywords: biodistribution; characterizing pharmacokinetics; therapeutic proteins; biodistribution therapeutic ... See more keywords
Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s317327
Abstract: Purpose Long-acting insulin analogues are known to be a major player in the management of glucose levels in type I diabetic patients. However, highly frequent hypo- and hyperglycemic incidences of current long-acting insulins are the… read more here.
Keywords: pharmacokinetics biodistribution; insulin; long acting; biodistribution excretion ... See more keywords
Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s121881
Abstract: Docetaxel is a highly potent anticancer agent being used in a wide spectrum of cancer types. There are important matters of concern regarding the drug’s pharmacokinetics related to the conventional formulation. Poly(lactide-co-glycolide) (PLGA) is a… read more here.
Keywords: application; pharmacokinetics biodistribution; plga; peg ... See more keywords