Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of l-dopa and its metabolite 3-O-methyldopa in combination with entacapone
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DOI: 10.1007/s00702-020-02267-y
Abstract: In the pharmacotherapy of patients with Parkinson’s disease (PD), entacapone reduces the peripheral metabolism of l-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t1/2) of l-dopa and increasing the area under the concentration curve (AUC).… read more here.
Keywords: catechol methyltransferase; val158met polymorphism; dopa; entacapone ... See more keywords