Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients
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DOI: 10.2174/1389200220666190701094756
Abstract: Background: The Pharmacokinetics of Methotrexate (MTX) has been reported to show significant inter-subject variability. MTX is metabolized by SHMT1 and transported by OATP1B1 and OATP1B3 both of which show genetic polymorphisms. The non-genetic and genetic… read more here.
Keywords: genetic factors; pharmacokinetics methotrexate; chinese patients; mtx ... See more keywords