Pharmacokinetics of the oral multikinase inhibitor regorafenib and its association with real‐world treatment outcomes
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DOI: 10.1007/s10637-021-01115-4
Abstract: Purpose Despite the established activity of regorafenib in metastatic colorectal cancer (CRC), gastrointestinal stromal tumor (GIST), and hepatocellular carcinoma (HCC), its toxicity profile has limited clinical use. We aimed to evaluate the pharmacokinetics of regorafenib… read more here.
Keywords: real world; treatment; regorafenib; oral multikinase ... See more keywords
Pharmacokinetics of Oral Levonorgestrel in Women After Roux-en-Y Gastric Bypass Surgery and in BMI-Matched Controls
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DOI: 10.1007/s11695-020-04447-x
Abstract: Background Women are advised to primarily use non-oral contraceptive alternatives after Roux-en-Y gastric bypass since it is not known if the surgery affects the pharmacokinetics of oral contraceptives. Methods This is a multi-center, open label,… read more here.
Keywords: roux gastric; gastric bypass; pharmacokinetics oral; bypass surgery ... See more keywords
Prednisolone pharmacokinetics after oral prednisone administration in paediatric patients with kidney transplant
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DOI: 10.1111/bcp.15610
Abstract: Glucocorticoids are 1 of the primary treatments in paediatric kidney transplantation. The aims of this study were: (i) to build a population pharmacokinetics (PPK) model of free prednisolone, which is the active form of prednisone,… read more here.
Keywords: pharmacokinetics oral; oral prednisone; prednisolone; kidney transplant ... See more keywords
Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach
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DOI: 10.3390/pharmaceutics14101986
Abstract: Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim of this study was to investigate the pharmacokinetics… read more here.
Keywords: pharmacokinetics oral; laparoscopic sleeve; lsg; oral omeprazole ... See more keywords