Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double‐Blind, Randomized, Placebo‐Controlled Phase 1 Clinical Study
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DOI: 10.1002/cpdd.389
Abstract: CORT125134 is an orally active, high‐affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit from the modulation of cortisol activity. This first‐in‐human study was conducted to evaluate the… read more here.
Keywords: safety tolerability; pharmacological effect; study; tolerability pharmacokinetics ... See more keywords
Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin
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DOI: 10.1002/ptr.7397
Abstract: Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti‐microorganisms, immunomodulation,… read more here.
Keywords: chemistry pharmacokinetics; pharmacokinetics pharmacological; chemistry; toxicity quercitrin ... See more keywords
Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
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DOI: 10.3389/fphar.2020.579332
Abstract: Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability have been… read more here.
Keywords: systematical review; hydroxysafflor yellow; pharmacological effects; yellow systematical ... See more keywords
Biotransformation, Pharmacokinetics, and Pharmacological Activities of Ginsenoside Rd Against Multiple Diseases
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DOI: 10.3389/fphar.2022.909363
Abstract: Panax ginseng C.A. Mey. has a history of more than 4000 years and is widely used in Asian countries. Modern pharmacological studies have proved that ginsenosides and their compounds have a variety of significant biological… read more here.
Keywords: pharmacokinetics pharmacological; ginsenoside multiple; biotransformation; pharmacological activities ... See more keywords