Pharmacokinetics of Polymyxin B in Hospitalized Adults with Cystic Fibrosis
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DOI: 10.1128/aac.00792-21
Abstract: The optimal polymyxin B dosage needed to achieve an efficacy target of 50 to 100 mg · h/liter when treating multidrug-resistant bacterial infections in adult cystic fibrosis (CF) patients is unclear. The pharmacokinetics of intravenous polymyxin… read more here.
Keywords: cystic fibrosis; polymyxin; intravenous polymyxin; polymyxin hospitalized ... See more keywords
Population Pharmacokinetics of Polymyxin B in Acutely Ill Adult Patients
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DOI: 10.1128/aac.01475-17
Abstract: ABSTRACT Polymyxin B (PB) has reemerged as a common treatment against multidrug-resistant Gram-negative pathogens. However, nephrotoxicity remains a significant dose-limiting side effect, and contemporary pharmacokinetic (PK) data are limited. This study sought to evaluate PB… read more here.
Keywords: acutely ill; polymyxin acutely; population pharmacokinetics; pharmacokinetics polymyxin ... See more keywords