Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaa239
Abstract: Abstract Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and… read more here.
Keywords: pharmacokinetics remdesivir; ill patients; critically ill; remdesivir 441524 ... See more keywords
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac234
Abstract: Abstract Background Remdesivir is the first antiviral drug against SARS-CoV-2 approved for use in COVID-19 patients. Objectives To study the pharmacokinetic inter-individual variability of remdesivir and its main metabolite GS-441524 in a real-world setting of… read more here.
Keywords: metabolite 441524; remdesivir main; interpatient variability; variability ... See more keywords