Pharmacokinetics and Safety of Vibegron 75 mg Administered as an Intact or Crushed Tablet in Healthy Adults
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1169
Abstract: Oral pharmacotherapy for overactive bladder, a condition that increases with age, includes anticholinergics and β3‐adrenergic receptor agonists. Older adults, including those with dysphagia, may have difficulty swallowing tablets. In this phase 1 study in healthy… read more here.
Keywords: vibegron; pharmacokinetics safety; tablet; healthy adults ... See more keywords
Pharmacokinetics and Safety of Risperidone Subcutaneous Implants in Stable Patients With Schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.428
Abstract: A subcutaneous risperidone implant (RI) formulation was developed to improve medication adherence in schizophrenia. Two phase 1 studies were conducted to evaluate the pharmacokinetics of RI in adult patients with schizophrenia. In study 1, all… read more here.
Keywords: concentration; pharmacokinetics safety; oral risperidone; patients schizophrenia ... See more keywords
Systemic Pharmacokinetics, Safety, and Preliminary Efficacy of Topical AhR Agonist Tapinarof: Results of a Phase 1 Study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.439
Abstract: Tapinarof cream is a novel topical nonsteroidal agent that represents a unique class of anti‐inflammatory molecules targeting the aryl hydrocarbon receptor. Study 201851 was an open‐label, 2‐cohort sequential study that assessed the systemic pharmacokinetics, safety,… read more here.
Keywords: tapinarof; efficacy; pharmacokinetics safety; systemic pharmacokinetics ... See more keywords
Evaluation of Pharmacokinetics, Safety, and Drug‐Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.925
Abstract: Intravenous (IV) edaravone is approved as an amyotrophic lateral sclerosis (ALS) treatment. Because IV administration places a burden on patients, development of orally administered ALS treatments is needed. Therefore, 2 phase 1 studies of oral… read more here.
Keywords: formulation; edaravone healthy; drug; edaravone ... See more keywords
Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25747
Abstract: Vaginal rings are a promising approach to provide a woman‐centred, long‐acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction of… read more here.
Keywords: vaginal rings; phase pharmacokinetics; safety; pharmacokinetics safety ... See more keywords
The effect of potent CYP2D6 inhibition on the pharmacokinetics and safety of deutetrabenazine in healthy volunteers.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-021-03202-0
Abstract: PURPOSE Deutetrabenazine is a deuterated form of tetrabenazine with a confirmed lower rate of CYP2D6 metabolism of the active metabolites, α- and β-HTBZ. In this study, we assessed the effect of paroxetine, a potent CYP2D6… read more here.
Keywords: safety deutetrabenazine; safety; potent cyp2d6; effect ... See more keywords
Pharmacokinetics and safety of rilpivirine in healthy Japanese subjects and exploration of ethnic sensitivity of rilpivirine pharmacokinetics with physiologically based pharmacokinetic model approach.
Sign Up to like & getrecommendations! Published in 2021 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2021.100422
Abstract: Rilpivirine is a non-nucleoside reverse transcriptase inhibitor, used for the treatment of human immunodeficiency virus type-1 infection. An open label study was conducted to investigate the pharmacokinetics (PK) and safety of a single oral dose… read more here.
Keywords: rilpivirine; physiologically based; model; pharmacokinetics safety ... See more keywords
Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.05.019
Abstract: &NA; Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate… read more here.
Keywords: diabetes review; cinnamaldehyde diabetes; safety; pharmacology ... See more keywords
Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.
Sign Up to like & getrecommendations! Published in 2020 at "Planta medica"
DOI: 10.1055/a-1212-5475
Abstract: Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is… read more here.
Keywords: mitragynine beagle; mitragynine; beagle dogs; safety mitragynine ... See more keywords
Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz497
Abstract: Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) and efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study… read more here.
Keywords: safety; aztreonam avibactam; min; pharmacokinetics safety ... See more keywords
A phase II study to evaluate the pharmacokinetics, safety, and tolerability of Risperidone ISM multiple intramuscular injections once every 4 weeks in patients with schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000203
Abstract: This study characterized the pharmacokinetics, safety, and tolerability of Risperidone ISM, a new long-acting intramuscular formulation, for monthly administration without oral supplementation. Patients with schizophrenia received multiple intramuscular injections of 75 mg in the gluteal or… read more here.
Keywords: risperidone ism; study; intramuscular injections; multiple intramuscular ... See more keywords