Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC–MS/MS and its application to a pharmacokinetics study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.10.034
Abstract: HighlightsA simple, rapid and efficient pretreatment of AF‐HF001 is reported.A full validated LC–MS/MS method of AF‐HF001 is described for the first time.Successful application to a pharmacokinetics study of AF‐HF001 in mice plasma.First mice pharmacokinetics report… read more here.
Keywords: application pharmacokinetics; isonicotinylhydrazide derivative; positive inotropic; hf001 ... See more keywords
Povidone-iodine pharmacokinetics and study design
Sign Up to like & getrecommendations! Published in 2020 at "BMC Ophthalmology"
DOI: 10.1186/s12886-020-1313-9
Abstract: Dr. Gnanasekaran et al. reported the bactericidal activity of various concentrations of povidone iodine (PI) solution in an agar plate experiment of respiratory flora. The study design and the pharmacokinetic properties of PI solution ensured… read more here.
Keywords: methodology; povidone iodine; study design; ophthalmology ... See more keywords
The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer
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DOI: 10.34133/research.0126
Abstract: Serving as targeting ligands, aptamers have shown promise in precision medicine. However, the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’ clinical translation. To bridge this gap,… read more here.
Keywords: dynamic pharmacokinetics; body; biosafety; human body ... See more keywords