Effects of rhein and Rheum palmatum L. extract on the pharmacokinetics and tissue distribution of aristolochic acid I and its demethylated metabolite in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113537
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Aristolochic acid nephropathy (AAN) is a kidney disease caused by the administration of plants containing aristolochic acids (AAs). Aristolochic acid I (AAI) is the main toxic component in AAs. Organic anion transporters (OATs)… read more here.
Keywords: tissue distribution; pharmacokinetics tissue; aai; aai aaia ... See more keywords
Pharmacokinetics and tissue distribution of methcathinone in rabbits.
Sign Up to like & getrecommendations! Published in 2021 at "Legal medicine"
DOI: 10.1016/j.legalmed.2021.101876
Abstract: Methcathinone is one of the most commonly abused designer narcotics. The pharmacokinetics and tissue distribution of methcathinone is not well understood. In this study, methcathinone was intravenously or intragastrically administered to rabbits in order to… read more here.
Keywords: distribution methcathinone; tissue distribution; tissue; pharmacokinetics tissue ... See more keywords
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
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DOI: 10.1038/s41401-020-00537-9
Abstract: Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to… read more here.
Keywords: rdv; nucleotide monophosphate; triphosphate; remdesivir ... See more keywords
Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Planta medica"
DOI: 10.1055/a-0851-6879
Abstract: Aegeline is claimed to be a biologically active constituent of Aegle marmelos. Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight… read more here.
Keywords: tissue distribution; pharmacokinetics tissue; distribution aegeline; oral administration ... See more keywords
Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration
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DOI: 10.1080/00498254.2020.1747119
Abstract: Abstract Plasma pharmacokinetics (PK) and tissue disposition of enrofloxacin (EFX) was studied in rainbow trout (Oncorhynchus mykiss) after a single oral administration of 10 mg/kg, and by immersion baths of 20 ppm during 2.5 h and 100 ppm during… read more here.
Keywords: administration; tissue disposition; disposition enrofloxacin; pharmacokinetics tissue ... See more keywords
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats
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DOI: 10.1080/00498254.2022.2048323
Abstract: Abstract Macleaya cordata extracts (MCE) are listed as feed additives in animal production by the European Food Authority. The core components of MCE are mainly sanguinarine (SA) and chelerythrine (CHE). This study aims to investigate… read more here.
Keywords: macleaya cordata; sex differences; tissue residues; pharmacokinetics tissue ... See more keywords
Plasma pharmacokinetics and tissue depletion of cyromazine and its metabolite melamine following oral administration in laying chickens
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DOI: 10.1111/jvp.12379
Abstract: The study was designed to characterize the plasma pharmacokinetics and tissue depletion profiles (including eggs) of cyromazine (CYR) in chickens following oral administration alone or in combination with melamine (MEL). In order to assess the… read more here.
Keywords: pharmacokinetics tissue; tissue depletion; cyr; tissue ... See more keywords
Development and validation of a sensitive UPLC-Q-TOF-MS/MS for the measurement of nine components in rat plasma and tissues and its application to pharmacokinetics and tissue distribution studies with Xuanfei Baidu granules.
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DOI: 10.2174/1389200223666220215151245
Abstract: BACKGROUND Xuanfei Baidu granules (XFBD granules) are based on the prescription of Xuanfei Baidu, which showed promise as a first-line treatment against Corona Virus Disease 2019 (COVID-19) in Wuhan, Hubei. On March 2, 2021, XFBD… read more here.
Keywords: tissue distribution; xuanfei baidu; xfbd granules; pharmacokinetics tissue ... See more keywords
Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats
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DOI: 10.3389/fphar.2019.00034
Abstract: Aging is an inevitable biological process characterized by the loss of functional capacity and associated with changes in all phases of pharmacokinetic processes. Naringin, a dietary flavanone glycoside, has been proved to be beneficial for… read more here.
Keywords: aged rats; tissue distribution; pharmacokinetics tissue; naringin aged ... See more keywords
Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness
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DOI: 10.3389/fphar.2020.00190
Abstract: Paeonol is a major bioactive ingredient in Moutan Cortex (the root barks of Paeonia suffruticosa Andrews) and exhibited a wide range of bioactivities such as anti-inflammation, anti-oxidation, hypoglycemic effect, analgesic, and others. Even though paeonol… read more here.
Keywords: excretion; paeonol; paeonol major; pharmacokinetics tissue ... See more keywords
Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1036732
Abstract: Objective: Curcumol is one of the major active ingredients isolated from the traditional Chinese medicine Curcumae Rhizoma and is reported to exhibit various bioactivities, such as anti-tumor and anti-liver fibrosis effects. However, studies of curcumol… read more here.
Keywords: curcumol; protein binding; plasma; tissue distribution ... See more keywords