Pharmacokinetics and tolerability of oral dosage forms of huperzine a in healthy Chinese male volunteers: a randomized, single dose, three-period, six-sequence crossover study
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DOI: 10.1007/s11596-017-1807-8
Abstract: SummaryHuperzine A is a potent, reversible, and blood-brain barrier permeable acetylcholinesterase inhibitor. The aim of this study was to compare the pharmacokinetics, tolerability, and bioavailability of two formulations with the established reference formulation of huperzine… read more here.
Keywords: randomized single; healthy chinese; chinese male; pharmacokinetics tolerability ... See more keywords
Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects With and Without Renal Impairment
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DOI: 10.1007/s40262-017-0528-2
Abstract: AbstractBackgroundThe pharmacokinetics and tolerability of semaglutide, a once-weekly human glucagon-like peptide-1 analog in development for the treatment of type 2 diabetes mellitus, were investigated in subjects with/without renal impairment (RI). MethodsFifty-six subjects, categorized into renal function… read more here.
Keywords: human glucagon; semaglutide; glucagon like; pharmacokinetics tolerability ... See more keywords
Pharmacokinetics and tolerability of ABX464, a novel first-in-class compound to treat HIV infection, in healthy HIV-uninfected subjects
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DOI: 10.1093/jac/dkw458
Abstract: Background: An anti-HIV compound (ABX464) has been developed with a novel mechanism of activity in that it blocks viral gene expression in cells that are already infected. Objectives: A first-in-man study was conducted to determine… read more here.
Keywords: hiv infection; abx464 nglc; abx464; pharmacokinetics tolerability ... See more keywords
Pharmacokinetics and tolerability of a new formulation of omeprazole in the horse
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DOI: 10.1111/jvp.12371
Abstract: A new formulation of omeprazole in gastro-resistant granules was tested with regard to its pharmacokinetics and tolerability. Twenty-four horses were randomly divided into three groups (8 horses/group) and treated, according a parallel study design, as… read more here.
Keywords: formulation omeprazole; new formulation; pharmacokinetics tolerability; group ... See more keywords
Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants
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DOI: 10.1136/archdischild-2022-323807
Abstract: Objectives Intranasal nalbuphine could be a safe, efficacious and non-invasive alternative to parenteral pain medication in infants. We aimed to assess pharmacokinetics (PK) and tolerability of intranasal and intravenous nalbuphine administration in infants. Methods Prospective… read more here.
Keywords: administration; pharmacokinetics tolerability; tolerability intranasal; intranasal intravenous ... See more keywords
Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s126861
Abstract: Objective DA-8031 is a selective serotonin reuptake inhibitor under development for the treatment of premature ejaculation. This is the first-in-human study aimed at evaluating the pharmacokinetics and tolerability of DA-8031 and its metabolites (M1, M2,… read more here.
Keywords: selective serotonin; serotonin reuptake; tolerability 8031; pharmacokinetics tolerability ... See more keywords