Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response.
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DOI: 10.1007/s12012-021-09680-z
Abstract: Complete vascular occlusion to distant tissue prior to an ischemic cardiac event can provide significant cardioprotection via remote ischemic preconditioning (RIPC). Despite understanding its mechanistic basis, its translation to clinical practice has been unsuccessful, likely… read more here.
Keywords: response; preconditioning response; vascular occlusion; pharmacologic inhibition ... See more keywords
Genetic or pharmacologic inhibition of EGFR ameliorates sepsis-induced AKI
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DOI: 10.18632/oncotarget.21244
Abstract: Despite recent studies have demonstrated that the EGF receptor (EGFR) activation provided a renoprotective role during ischemic and folic acid-induced AKI, the role and regulation mechanism of EGFR in septic AKI remains unclear. Here, gefitinib,… read more here.
Keywords: egfr; genetic pharmacologic; induced aki; pharmacologic inhibition ... See more keywords
Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor
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DOI: 10.3727/096504017x14992942781895
Abstract: Wilms tumor (WT) is the most common renal malignancy in children and the fourth most common pediatric solid malignancy in the US. Although the mechanisms underlying the WT biology are complex, these tumors most often… read more here.
Keywords: inhibition catenin; catenin; pyrvinium inhibits; wilms tumor ... See more keywords