Pharmacologic modulation of intracellular Na+ concentration with ranolazine impacts inflammatory response in humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207020119
Abstract: Significance Inflammation is a key process accompanying cardiovascular disease. Reducing inflammation is therefore an important therapeutic option. We provide evidence, that Na+ and Ca2+ modulation regulate the inflammatory response. Reducing intracellular Na+ pharmacologically using the… read more here.
Keywords: inflammation; modulation; inflammatory response; ranolazine ... See more keywords
Pharmacologic modulation of nasal epithelium augments neural stem cell targeting of glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.29581
Abstract: Glioblastoma (GBM) remains the most lethal and untreatable central nervous system malignancy. The challenges to devise novel and effective anti-tumor therapies include difficulty in locating the precise tumor border for complete surgical resection, and rapid… read more here.
Keywords: glioblastoma; non invasive; pharmacologic modulation; neural stem ... See more keywords