Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
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DOI: 10.1126/sciadv.abk2252
Abstract: The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We… read more here.
Keywords: overexpression; proteasome; genetic pharmacologic; pathology ... See more keywords