Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
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DOI: 10.1038/s41467-022-28683-0
Abstract: Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed to maximize metabolic benefits with reduced side-effects,… read more here.
Keywords: glp; glp glucagon; glucagon; gipr glp ... See more keywords
Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (Artemisia absinthium)
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DOI: 10.3390/antibiotics9060353
Abstract: Plants have been used since ancient times to cure certain infectious diseases, and some of them are now standard treatments for several diseases. Due to the side effects and resistance of pathogenic microorganisms to antibiotics… read more here.
Keywords: compounds pharmacological; actions pharmacokinetics; artemisia absinthium; pharmacological actions ... See more keywords
Pharmacological Actions of 5-Hydroxyindolin-2 on Modulation of Platelet Functions and Thrombus Formation via Thromboxane A2 Inhibition and cAMP Production
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DOI: 10.3390/ijms232314545
Abstract: Platelets play a very significant role in hemostasis while simultaneously posing a risk for the development of various cardiovascular diseases. Platelet-mediated issues can occur in blood vessels and trigger various medical problems. Therefore, controlling platelet… read more here.
Keywords: actions hydroxyindolin; modulation platelet; hydroxyindolin modulation; pharmacological actions ... See more keywords
Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases
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DOI: 10.3390/molecules24050995
Abstract: Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1. Capsazepine can exhibit diverse effects on cancer (prostate cancer, breast cancer, colorectal cancer, oral cancer, and osteosarcoma) growth and survival,… read more here.
Keywords: synthetic analogue; analogue capsaicin; capsazepine synthetic; pharmacological actions ... See more keywords
The Spectrum of Pharmacological Actions of Syringetin and Its Natural Derivatives—A Summary Review
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DOI: 10.3390/nu14235157
Abstract: Mono- and poly-O-methylated flavonols and their glycoside derivatives belong to the group of natural plant polyphenols with a wide spectrum of pharmacological activities. These compounds are known for their antioxidant, antimutagenic, hepatoprotective, antidiabetic, and antilipogenic… read more here.
Keywords: derivatives summary; actions syringetin; pharmacological actions; spectrum pharmacological ... See more keywords
New Paradigms of Old Psychedelics in Schizophrenia
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DOI: 10.3390/ph15050640
Abstract: Psychedelics such as lysergic acid diethylamide (LSD), psilocybin (magic mushrooms), and mescaline exhibit intense effects on the human brain and behaviour. In recent years, there has been a surge in studies investigating these drugs because… read more here.
Keywords: new paradigms; paradigms old; pharmacological actions; old psychedelics ... See more keywords