Methodological aspects and pharmacological applications of three-dimensional cancer cell cultures and organoids.
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DOI: 10.1016/j.lfs.2020.117784
Abstract: Two-dimensional (2D) cell cultures, in which cells grow in flat layers on plastic surfaces, are considered the standard model for use in drug screening and for biological assays. However, these models do not accurately represent… read more here.
Keywords: three dimensional; pharmacological applications; methodological aspects; aspects pharmacological ... See more keywords
Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose
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DOI: 10.1039/c7ra08502h
Abstract: We synthesized polymeric prodrugs in which ibuprofen (IBU) was conjugated in a one-pot preparation to the hydrophilic polysaccharide hydroxyethylcellulose (HEC). The amphiphilic conjugates formed nanoparticles of 450–700 nm diameter at a water/DMSO interface. Synthesized HEC-IBU… read more here.
Keywords: pharmacological applications; applications ibuprofen; characterization pharmaceutical; ibuprofen conjugates ... See more keywords
A literature perspective on the pharmacological applications of yohimbine
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DOI: 10.1080/07853890.2022.2131330
Abstract: Abstract Introduction: Phytochemicals have garnered much attention because they are useful in managing several human diseases. Yohimbine is one such phytochemical with significant pharmacological potential and could be exploited for research by medicinal chemists. It… read more here.
Keywords: yohimbine; pharmacological applications; literature perspective; perspective pharmacological ... See more keywords
Pharmacological applications of farnesol (C15H26O): a patent review
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DOI: 10.1080/13543776.2020.1718653
Abstract: ABSTRACT Introduction: Farnesol (C15H26O) is a sesquiterpene alcohol found in essential oils. This substance is reported to have different pharmacological activities such as antimicrobial, antitumor and antioxidant effects, as well as actions in different body… read more here.
Keywords: patent review; farnesol c15h26o; pharmacological applications; c15h26o patent ... See more keywords
Biological Activities and Pharmacological Applications of Cyclodextrins Complexed with Essential Oils and Their Volatile Components: A Systematic Review.
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DOI: 10.2174/1381612824666181120093634
Abstract: BACKGROUND Essential oils (EOs) and their volatile components (VCs) have varied biological and pharmacological activities, but low solubility and bioavailability hamper their applications, so that inclusion in cyclodextrins (CDs) is likely to improve their physicochemical… read more here.
Keywords: biological activities; pharmacological applications; activities pharmacological; systematic review ... See more keywords
Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs
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DOI: 10.3390/ijms20082025
Abstract: Oxidative stress (OS) is associated with many diseases ranging from cancer to neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of the most effective cytoprotective controller against OS. Modulation of Nrf2 pathway… read more here.
Keywords: nrf2 inhibitors; potential antineoplastic; pharmacological applications; nrf2 pathway ... See more keywords
Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications
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DOI: 10.3390/ijms24032937
Abstract: Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in the pharmaceutical industry. Their derivatives are present in more than twenty classes of pharmaceuticals, as well as alkaloids.… read more here.
Keywords: synthesis pharmacological; pharmacological applications; piperidine derivatives; advances synthesis ... See more keywords
Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
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DOI: 10.3390/md15060173
Abstract: Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one… read more here.
Keywords: sponges bacteria; pharmacological applications; bacteria challenging; enzyme inhibitors ... See more keywords