Inhibition of Peroxide Removal Enhances Pharmacological Ascorbate and Ionizing Radiation-Induced Cytotoxicity of Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.144
Abstract: Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer deaths with a poor 5 year survival rate of only 8.2%. PDA cells produce high levels of reactive oxygen species (ROS) compared to normal… read more here.
Keywords: ascorbate; peroxide removal; pda; pharmacological ascorbate ... See more keywords
Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101804
Abstract: Pharmacological ascorbate (P-AscH-) combined with standard of care (SOC) radiation and temozolomide is being evaluated in a phase 2 clinical trial (NCT02344355) in the treatment of glioblastoma (GBM). Previously published data demonstrated that paramagnetic iron… read more here.
Keywords: asch; fe3 fe2; biomarker; pharmacological ascorbate ... See more keywords
Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.989000
Abstract: Pharmacological ascorbate (i.e., intravenous infusions of vitamin C reaching ~ 20 mM in plasma) is under active investigation as an adjuvant to standard of care anti-cancer treatments due to its dual redox roles as an… read more here.
Keywords: pharmacological ascorbate; novel therapeutic; ascorbate novel; ascorbate ... See more keywords
Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate
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DOI: 10.3390/antiox10040614
Abstract: Pancreatic cancer cells (PDACs) are more susceptible to an oxidative insult than normal cells, resulting in greater cytotoxicity upon exposure to agents that increase pro-oxidant levels. Pharmacological ascorbate (P-AscH−), i.e., large amounts given intravenously (IV),… read more here.
Keywords: normal cells; pancreatic cancer; cancer cells; pharmacological ascorbate ... See more keywords
Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910880
Abstract: Interest in the use of pharmacological ascorbate as a treatment for cancer has increased considerably since it was introduced by Cameron and Pauling in the 1970s. Recently, pharmacological ascorbate has been used in preclinical and… read more here.
Keywords: cancer; cancer therapy; pharmacological ascorbate; hydrogen peroxide ... See more keywords
Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation
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DOI: 10.7150/thno.21745
Abstract: Rationale: The antitumor activity of high-dose ascorbate has been re-evaluated recently, but the mechanism underlying cell-specific sensitivity to ascorbate has not yet been clarified. Methods: The effects of high-dose ascorbate on gastric cancer were assessed… read more here.
Keywords: ascorbate; gastric cancer; expression; cancer cells ... See more keywords