Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: preclinical and clinical data.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105976
Abstract: Seizures are relatively common in cancer patients, and co-administration of chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many cases. Nonetheless, clinically relevant interactions between chemotherapeutic drugs and AEDs are rarely summarized… read more here.
Keywords: interactions alkylating; alkylating agents; pharmacological interactions; relevant pharmacological ... See more keywords
CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15551
Abstract: Patients on treatment with oral fixed dose imatinib are frequently under‐ or overexposed to the drug. We investigated the association between the gene activity score (GAS) of imatinib‐metabolizing cytochromes (CYP3A4, CYP3A5, CYP2D6, CYP2C9, CYP2C19, CYP2C8)… read more here.
Keywords: imatinib; pharmacological interactions; pharmacogenetics pharmacological; cyp2d6 cyp2c8 ... See more keywords
A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions
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DOI: 10.3389/fphar.2018.01379
Abstract: The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases,… read more here.
Keywords: inhibitor; compound nsc13626; pharmacological interactions; selective jak2 ... See more keywords
Pharmacological Interactions in the Elderly
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DOI: 10.3390/medicina56070320
Abstract: Pharmacological therapy in the elderly is particularly complicated and challenging. Due to coexistence of three main predisposing factors (advanced age, multiple morbidity and polypharmacotherapy), this group of patients is prone to occurrence of drug interactions… read more here.
Keywords: drug; pharmacological interactions; drug interactions; interactions elderly ... See more keywords