Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone).
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2502
Abstract: Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize… read more here.
Keywords: ethylnorpentylone; analytical quantification; ethylpentylone ephylone; pharmacological mechanism ... See more keywords
Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs.
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DOI: 10.1016/j.canlet.2020.02.015
Abstract: Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the intracellular microenvironment, which is under the constitutive control of glutathione peroxidase 4 (GPX4). Ferrous iron (Fe2+) accumulation and lipid peroxidation are… read more here.
Keywords: novel pharmacological; mechanism anti; ferroptosis; ferroptosis novel ... See more keywords
Dissection of the potential pharmacological mechanism of Rhizoma coptidis water extract against inflammation in diabetes mellitus via chemical profiling, network pharmacology and experimental validation
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DOI: 10.1039/d1nj02812j
Abstract: Elucidating the therapeutical basis and functional mechanism of traditional Chinese medicine (TCM) is still a challenge faced by researchers since the effects of TCM are always achieved by the interactions of multiple components and multiple… read more here.
Keywords: mechanism rhizoma; potential pharmacological; mechanism; pharmacology ... See more keywords
Comparative efficacy and pharmacological mechanism of Chinese patent medicines against anthracycline-induced cardiotoxicity: An integrated study of network meta-analysis and network pharmacology approach
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DOI: 10.3389/fcvm.2023.1126110
Abstract: Background This study aimed to evaluate the efficacy of Chinese patent medicines (CPMs) combined with dexrazoxane (DEX) against anthracycline-induced cardiotoxicity (AIC) and further explore their pharmacological mechanism by integrating the network meta-analysis (NMA) and network… read more here.
Keywords: pharmacology; dex; pharmacological mechanism; network pharmacology ... See more keywords
The Pharmacological Mechanism of Guchangzhixie Capsule Against Experimental Colitis
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DOI: 10.3389/fphar.2021.762603
Abstract: Ulcerative colitis (UC) is the major type of inflammatory bowel disease (IBD) characterized by an overactive immune response and destruction of colorectal epithelium with intricate pathological factors. Guchangzhixie (GCZX) capsule, included in the Chinese Pharmacopoeia… read more here.
Keywords: pharmacological mechanism; experimental colitis; gczx capsule; pharmacology ... See more keywords