The paradoxical pharmacological mechanisms of lenalidomide and bortezomib in the treatment of multiple myeloma.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001041
Abstract: The combination of bortezomib (Velcade, PS-341) and lenalidomide (Revlimid) for the treatment of multiple myeloma was proved by USA Food and Drug Administration in 2006. Lenalidomide prevents the proliferation of multiple myeloma cells through binding… read more here.
Keywords: myeloma; multiple myeloma; pharmacological mechanisms; paradoxical pharmacological ... See more keywords
Application and prospects of butylphthalide for the treatment of neurological diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000289
Abstract: OBJECTIVE 3-N-butylphthalide (NBP) comprises one of the chemical constituents of celery oil. It has a series of pharmacological mechanisms including reconstructing microcirculation, protecting mitochondrial function, inhibiting oxidative stress, and inhibiting neuronal apoptosis and etc. Based… read more here.
Keywords: application; application nbp; neurological diseases; pharmacological mechanisms ... See more keywords
Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s272442
Abstract: Objective This study aimed to evaluate the pharmacological mechanisms of antiviral drugs against the novel coronavirus disease (COVID-19) and the study designs in clinical trials registered with the International Clinical Trials Registry Platform (ICTRP). Methods… read more here.
Keywords: antiviral drugs; study; pharmacological mechanisms; clinical trials ... See more keywords
Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s360790
Abstract: Purpose This study was designed to evaluate the pharmacological mechanisms of Aloin against gastric cancer (GC) via network pharmacology analysis combined with experimental verification. Methods Using network pharmacology methods, the potential targets of Aloin and… read more here.
Keywords: network; mechanisms aloin; pharmacology; analysis ... See more keywords
Unveiling the Pharmacological Mechanisms of Eleutheroside E Against Postmenopausal Osteoporosis Through UPLC-Q/TOF-MS-Based Metabolomics
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01316
Abstract: Postmenopausal osteoporosis (PMOP) is a common metabolic bone disease in postmenopausal women in the Worldwide, and seriously affects the quality of life of middle-aged and elderly women. Therefore, there is an urgent need to discover… read more here.
Keywords: postmenopausal osteoporosis; pmop; uplc tof; pharmacological mechanisms ... See more keywords
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.844685
Abstract: Purpose: To explore pharmacological mechanisms of Pulsatilla decoction (PD) against Crohn’s disease (CD) via network pharmacology analysis followed by experimental validation. Methods: Public databases were searched to identify bioactive compounds and related targets of PD… read more here.
Keywords: network; pharmacology; disease; pharmacological mechanisms ... See more keywords
Curcumin against gastrointestinal cancer: A review of the pharmacological mechanisms underlying its antitumor activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.990475
Abstract: Gastrointestinal cancer (GIC) poses a serious threat to human health globally. Curcumin (CUR), a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, has shown reliable anticancer function and low toxicity, thereby offering broad research… read more here.
Keywords: antitumor; gastrointestinal cancer; review; mechanisms underlying ... See more keywords
Therapeutics of Charcot neuroarthropathy and pharmacological mechanisms: A bone metabolism perspective
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1160278
Abstract: Charcot neuroarthropathy (CN) is a chronic, destructive, and painless damage of the skeletal system that affects the life quality of patients. CN, with an unclear mechanism, is characterized with invasive destruction of bones and a… read more here.
Keywords: metabolism; bone metabolism; charcot neuroarthropathy; mechanisms bone ... See more keywords