Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51481
Abstract: The primary dystonia DYT6 is caused by mutations in the transcription factor Thanatos-associated protein 1 (THAP1). To understand THAP1's functions, we generated mice lacking THAP1 in the nervous system. THAP1 loss causes locomotor deficits associated… read more here.
Keywords: receptor responses; deficits receptor; reveals deficits; pharmacological perturbation ... See more keywords
Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104682
Abstract: Direct cell reprogramming, also called transdifferentiation, is valuable for cell fate studies and regenerative medicine. Current approaches to transdifferentiation are usually achieved by directly targeting the nuclear functions, such as manipulating the lineage‐specific transcriptional factors,… read more here.
Keywords: cell; pharmacological perturbation; transdifferentiation; fibroblasts neurons ... See more keywords