Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPARγ agonists.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.051
Abstract: In this structure-activity relationship study, the influence of aryl substituents at position 5 or 6 on the pharmacological profile of the partial PPARγ agonist 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid was investigated. This lead was previously identified as the… read more here.
Keywords: ppar; pharmacological profile; benzo imidazol; imidazol methyl ... See more keywords
Pharmacological profile of vascular activity of human stem villous arteries.
Sign Up to like & getrecommendations! Published in 2019 at "Placenta"
DOI: 10.1016/j.placenta.2019.09.009
Abstract: INTRODUCTION The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed conditions potentially… read more here.
Keywords: stem villous; vasculature; villous arteries; pharmacological profile ... See more keywords
Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00437
Abstract: Cushing's disease, characterized by elevated plasma cortisol levels, can be controlled by inhibition of 11β-hydroxylase (CYP11B1). The previously identified selective and potent CYP11B1 inhibitor 5-((5-methylpyridin-3-yl)methyl)-2-phenylpyridine Ref 7 (IC50= 2 nM) exhibited promutagenic potential as well… read more here.
Keywords: cushing disease; pharmacological profile; lead optimization; optimization generates ... See more keywords
Opposite alterations of 5HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01430-7
Abstract: The status of serotonin 5HT 2A receptors (5HT 2A Rs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5HT 2A R… read more here.
Keywords: inverse agonist; pharmacological profile; subjects schizophrenia; density ... See more keywords
Compendium of naringenin: Potential sources, analytical aspects, chemistry, nutraceutical potentials and pharmacological profile.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2056726
Abstract: Naringenin is flavorless, water insoluble active principle belonging to flavanone subclass. It exhibits a diverse pharmacological profile as well as divine nutraceutical values. Although several researchers have explored this phytoconstituent to evaluate its promising properties,… read more here.
Keywords: pharmacological profile; compendium naringenin; chemistry; potential sources ... See more keywords
Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15700
Abstract: Activated coagulation factor XI (FXIa) contributes to the development and propagation of thrombosis but plays only a minor role in hemostasis; therefore, it is an attractive antithrombotic target. read more here.
Keywords: profile asundexian; pharmacological profile; asundexian novel; novel orally ... See more keywords
The phytochemical and pharmacological profile of taraxasterol
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.927365
Abstract: Taraxasterol is one of the bioactive triterpenoids found in dandelion, a member of the family Asteraceae. In the animal or cellular models of several ailments, including liver damage, gastritis, colitis, arthritis, pneumonia, tumors, and immune… read more here.
Keywords: pharmacological profile; taraxasterol; profile taraxasterol; phytochemical pharmacological ... See more keywords
The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158277
Abstract: Pyrovalerone cathinones are potent psychoactive substances that possess a pyrrolidine moiety. Pyrovalerone-type novel psychoactive substances (NPS) are continuously detected but their pharmacology and toxicology are largely unknown. We assessed several pyrovalerone and related cathinone derivatives… read more here.
Keywords: pyrovalerone cathinones; related cathinone; pyrovalerone; pharmacological profile ... See more keywords
Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules27010104
Abstract: Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain. Apart from this, VPA has potential therapeutic applications in other central nervous… read more here.
Keywords: pharmacological profile; modifications valproic; insights structural; structural modifications ... See more keywords
Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165055
Abstract: The pharmacological attributes of turmeric have been extensively described and frequently related to the action of curcuminoids. However, there is also scientific evidence of the contribution of turmeric oil. Since the oil does not contain… read more here.
Keywords: pharmacological profile; profile bioactivities; turmeric oil; bioactivities safety ... See more keywords
Synthesis and Pharmacological Profile of Hydrazide Compounds
Sign Up to like & getrecommendations! Published in 2023 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2023.00163
Abstract: This class of compounds, which is known as Hydrazide has great significance in organic chemistry. This is the reason why methods of preparation of different types of compounds that are useful in many fields are… read more here.
Keywords: pharmacological profile; synthesis pharmacological; chemistry; hydrazide compounds ... See more keywords