Tryptophan Metabolism as a Pharmacological Target.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.11.006
Abstract: L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms. Enzymes involved… read more here.
Keywords: metabolism; tryptophan metabolism; metabolism pharmacological; pharmacological target ... See more keywords
Enkephalinases as a new pharmacological target in the treatment of gastrointestinal tract disorders
Sign Up to like & getrecommendations! Published in 2020 at "Postepy biochemii"
DOI: 10.18388/pb.2020_344
Abstract: Enkephalinases, which belong to the family of zinc metalloproteases play a crucial role in modulation of the endogenous opioid system (EOS) activity. Enkephalinase inhibitors (EI) allow obtaining therapeutic concentrations of selected endogenous peptides. One of… read more here.
Keywords: treatment gastrointestinal; treatment; new pharmacological; enkephalinases new ... See more keywords
Matrix Metalloproteinase 2 as a Pharmacological Target in Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15080920
Abstract: Heart failure (HF) is an acute or chronic clinical syndrome that results in a decrease in cardiac output and an increase in intracardiac pressure at rest or upon exertion. The pathophysiology of HF is heterogeneous… read more here.
Keywords: pharmacological target; heart failure; matrix metalloproteinase; heart ... See more keywords
The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041000
Abstract: The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19. However, some… read more here.
Keywords: pharmacological target; envelope protein; cov pharmacological; protein sars ... See more keywords
Friend or foe? Mitochondria as a pharmacological target in cancer treatment.
Sign Up to like & getrecommendations! Published in 2017 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2017-0110
Abstract: Mitochondria have acquired numerous functions over the course of evolution, such as those involved in controlling energy production, cellular metabolism, cell survival, apoptosis and autophagy within host cells. Tumor cells can develop defects in mitochondrial… read more here.
Keywords: foe mitochondria; mitochondria pharmacological; pharmacological target; target cancer ... See more keywords