Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism
Sign Up to like & getrecommendations! Published in 2019 at "Autism Research"
DOI: 10.1002/aur.2066
Abstract: Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA‐approved medical treatments exist for the diagnostic… read more here.
Keywords: models autism; mouse models; autism; pharmacological targets ... See more keywords
Intestinal adaptations following bariatric surgery: towards the identification of new pharmacological targets for obesity‐related metabolic diseases
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.08.002
Abstract: HIGHLIGHTSIntestinal glucose absorption, hormone secretion and barrier function are affected in obesity.Several intestinal adaptations are observed in subjects who undergo bariatric surgeries.Health benefits of bariatric surgeries involve all aforementioned functions of the intestine.Elucidating the molecular… read more here.
Keywords: surgery; bariatric surgeries; following bariatric; bariatric surgery ... See more keywords
Nuclear G-protein-coupled receptors as putative novel pharmacological targets.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.09.003
Abstract: Cell surface G-protein-coupled receptors (GPCRs) are targets for ˜30% of drugs currently on the market, and are the largest group of gene products targeted by drugs. Until recently, signaling mediated by GPCRs was thought to… read more here.
Keywords: novel pharmacological; protein coupled; pharmacological targets; coupled receptors ... See more keywords
Retinal biomarkers and pharmacological targets for Hermansky-Pudlak syndrome 7
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60931-5
Abstract: Deletion of dystrobrevin binding protein 1 has been linked to Hermansky-Pudlak syndrome type 7 (HPS-7), a rare disease characterized by oculocutaneous albinism and retinal dysfunction. We studied dysbindin-1 null mutant mice (Dys −/− ) to… read more here.
Keywords: hermansky pudlak; pharmacological targets; dys mice; mice ... See more keywords
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.971687
Abstract: The variant virus-based 2019 coronavirus disease (COVID-19) pandemic has reportedly impacted almost all populations globally, characterized by a huge number of infected individuals. Clinical evidence proves that patients with cancer are more easily infected with… read more here.
Keywords: pharmacology; targeting autophagy; covid; pharmacological targets ... See more keywords
Identifying potential pharmacological targets and mechanisms of vitamin D for hepatocellular carcinoma and COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.985781
Abstract: Coronavirus disease 2019 (COVID‐19) is a severe pandemic that has posed an unprecedented challenge to public health worldwide. Hepatocellular carcinoma (HCC) is a common digestive system malignancy, with high aggressiveness and poor prognosis. HCC patients… read more here.
Keywords: hepatocellular carcinoma; hcc; covid; covid hcc ... See more keywords
Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.858480
Abstract: Neuroblastomas are the main extracranial tumors that affect children, while glioblastomas are the most lethal brain tumors, with a median survival time of less than 12 months, and the prognosis of these tumors is poor… read more here.
Keywords: cell death; induction ferroptosis; ferroptosis focus; pharmacological targets ... See more keywords
Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.908772
Abstract: The tumor suppressor p53 is a well-known cellular guardian of genomic integrity that blocks cell cycle progression or induces apoptosis upon exposure to cellular stresses. However, it is unclear how the remaining activities of p53… read more here.
Keywords: translational modifications; modifications p53; post translational; pharmacological targets ... See more keywords
Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.929442
Abstract: Fucoxanthin (FX) is a special carotenoid having an allenic bond in its structure. FX is extracted from a variety of algae and edible seaweeds. It has been proved to contain numerous health benefits and preventive… read more here.
Keywords: fucoxanthin promising; promising phytochemical; phytochemical diverse; pharmacological targets ... See more keywords
Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets †
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25102331
Abstract: Several indole derivatives have been disclosed by our research groups that have been collaborating for nearly 25 years. The results of our investigations led to a variety of molecules binding selectively to different pharmacological targets,… read more here.
Keywords: indole scaffold; scaffold design; different pharmacological; pharmacological targets ... See more keywords
Newer potential pharmacological targets for autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2019 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_518_19
Abstract: A is a cluster of heterogeneous d i s o r d e r s w h i c h a r e neurodevelopmental and are distinctive by initial difficulties in social l ife, communication… read more here.
Keywords: potential pharmacological; spectrum disorder; pharmacological targets; autism spectrum ... See more keywords