Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores.
Sign Up to like & getrecommendations! Published in 2022 at "Cell calcium"
DOI: 10.1016/j.ceca.2022.102582
Abstract: Ca2+ signalling is of prime importance in controlling numerous cell functions in the brain. Endolysosomes are acidic organelles currently emerging as important Ca2+ stores in astrocytes, microglia, endothelial cells, and neurons. In neurons, these acidic… read more here.
Keywords: ca2 stores; functions pharmacological; neurophysiological functions; pharmacological tools ... See more keywords
Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2076675
Abstract: Abstract Proteolysis-targeting chimaeras (PROTACs) have been developed to be an emerging technology for targeted protein degradation and attracted the favour of academic institutions, large pharmaceutical enterprises, and biotechnology companies. The mechanism is based on the… read more here.
Keywords: protacs pharmacological; pharmacological tools; tools therapeutic; chimaeras protacs ... See more keywords
Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology
Sign Up to like & getrecommendations! Published in 2017 at "Current Neuropharmacology"
DOI: 10.2174/1570159x14666160928151546
Abstract: Background Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions… read more here.
Keywords: pharmacological tools; tools activate; physiology; function ... See more keywords
Enriching the Arsenal of Pharmacological Tools against MICAL2
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247519
Abstract: Molecule interacting with CasL 2 (MICAL2), a cytoskeleton dynamics regulator, are strongly expressed in several human cancer types, especially at the invasive front, in metastasizing cancer cells and in the neo-angiogenic vasculature. Although a plethora… read more here.
Keywords: pharmacological tools; mical2; enriching arsenal; ccg 1423 ... See more keywords