Analytical and pharmacological validation of the quantification of phenol red in a mouse model: An optimized method to evaluate expectorant drugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.106586
Abstract: INTRODUCTION The evaluation of expectorant activity has been extensively studied in murine models, involving the secretion of phenol red in the trachea or bronchus to estimate the secretory capacity of lower airway mucosa. However, differences… read more here.
Keywords: phenol; phenol red; expectorant drugs; pharmacological validation ... See more keywords
Pharmacological validation of a new IPF bleomycin-induced mouse model
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.pa1053
Abstract: Background: Drug discovery needs better animal models to mimic human features of idiopathic pulmonary fibrosis (IPF). As we previously reported1, double intratracheal (i.t.) instillation of bleomycin (BLM) produces a more severe and diffuse fibrosis compare… read more here.
Keywords: fibrosis; bleomycin; model; pharmacological validation ... See more keywords