Identifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neurons.
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DOI: 10.1016/j.bbrc.2020.02.019
Abstract: Low levels of brain-derived neurotrophic factor (BDNF), a key regulator of synaptic plasticity, are associated with neurological diseases, including depression and Alzheimer's disease. Therefore, BDNF is a drug target for these diseases. Here we screened… read more here.
Keywords: dipyrone; drug; expression pharmacologically; expression ... See more keywords