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   Articles with "pharmacology" as a keyword



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Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children

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recommendations! Published in 2022 at "JAMA network open"

DOI: 10.1001/jamanetworkopen.2022.29442

Abstract: IMPORTANCE Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults and is associated with poor short-term and long-term outcomes. Guidance is required to focus efforts related to expansion of… read more here.

Keywords: consensus; pharmacology; acute kidney; kidney ... See more keywords
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The missing, the short, and the long: Levodopa responses and dopamine actions

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recommendations! Published in 2017 at "Annals of Neurology"

DOI: 10.1002/ana.24961

Abstract: We attempt to correlate the clinical pharmacology of dopamine replacement therapy (DRT) in Parkinson Disease with known features of striatal dopamine actions. Despite its obvious impact, DRT does not normalize motor function, likely due to… read more here.

Keywords: missing short; long levodopa; short long; pharmacology ... See more keywords
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Influence of the pKa value on the antioxidant activity of licorice flavonoids under solvent‐mediated effects

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recommendations! Published in 2023 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200470

Abstract: Licorice flavonoids (LCFs) have been widely used in food care and medical treatment due to their significant antioxidant activities. However, the molecular mechanism of their antioxidant activity remains unclear. Therefore, network pharmacology, ADMET, density functional… read more here.

Keywords: antioxidant activity; pharmacology; pka; activity ... See more keywords
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Integrated analysis and network pharmacology approaches to explore key genes of Xingnaojing for treatment of Alzheimer's disease

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recommendations! Published in 2020 at "Brain and Behavior"

DOI: 10.1002/brb3.1610

Abstract: Alzheimer's disease (AD), as a neurodegenerative condition, is one of the leading causes of dementia. Our study aims to explore the key genes of Xingnaojing (XNJ) for treatment of AD by integrated microarray analysis and… read more here.

Keywords: alzheimer disease; explore key; key genes; pharmacology ... See more keywords
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Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202100689

Abstract: Apoptosis is a highly regulated cellular process. Aberration in apoptosis is a common characteristic of various disorders. Therefore, proteins involved in apoptosis are prime targets in multiple therapies. Bcl‐xL is an antiapoptotic protein. Compared to… read more here.

Keywords: pharmacology; based approaches; bcl; target platelet ... See more keywords
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Assessment of Bioactivity‐Modulating Pseudo‐Ring Formation in Psilocin and Related Tryptamines

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200183

Abstract: Psilocybin (1) is the major alkaloid found in psychedelic mushrooms and acts as a prodrug to psilocin (2, 4‐hydroxy‐N,N‐dimethyltryptamine), a potent psychedelic that exerts remarkable alteration of human consciousness. In contrast, the positional isomer bufotenin… read more here.

Keywords: psilocin; pharmacology; assessment bioactivity; ring formation ... See more keywords
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Applied pharmacology in percutaneous coronary intervention: You can't fight mother nature

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recommendations! Published in 2020 at "Catheterization and Cardiovascular Interventions"

DOI: 10.1002/ccd.29202

Abstract: Differential outcomes based on target vessel diameter persist in the era of second generation drug eluting stents. These differences are mainly driven by need for target vessel revascularization without appreciable differences in hard atherosclerotic cardiovascular… read more here.

Keywords: applied pharmacology; pharmacology percutaneous; pharmacology; percutaneous coronary ... See more keywords
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A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies

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recommendations! Published in 2022 at "Cancer"

DOI: 10.1002/cncr.34570

Abstract: Nelarabine is a purine nucleoside analogue prodrug approved for the treatment of relapsed and refractory T‐cell acute lymphoblastic leukemia (R/R T‐ALL) and lymphoblastic lymphoma (T‐LBL). Although effective in R/R T‐ALL, significant neurotoxicity is dose‐limiting and… read more here.

Keywords: pharmacology; study evaluate; relapsed refractory; evaluate safety ... See more keywords

A Dose-Confirmation Phase 1 Study to Evaluate the Safety and Pharmacology of Glucarpidase in Healthy Volunteers.

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recommendations! Published in 2021 at "Clinical pharmacology in drug development"

DOI: 10.1002/cpdd.1010

Abstract: Glucarpidase rapidly decomposes methotrexate. A phase 1 study of glucarpidase in an open-label, randomized parallel group was conducted to evaluate the safety, pharmacokinetics, and other pharmacologic effects in Japanese healthy volunteers without methotrexate treatment. A… read more here.

Keywords: glucarpidase; pharmacology; evaluate safety; phase study ... See more keywords
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Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1084

Abstract: Insulin aspart is a short‐acting insulin analogue that is used to control postprandial glycemia levels in diabetic patients. The aim of this clinical trial was to compare the pharmacokinetics and pharmacodynamics of GP40071 (GP‐Asp) and… read more here.

Keywords: clinical pharmacology; pharmacology; insulin aspart; hyperinsulinemic euglycemic ... See more keywords
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Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects

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recommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.645

Abstract: To evaluate the potential for ethnicity‐related differences in ataluren pharmacokinetics (PK) and safety, a phase 1 single‐dose study was conducted in 48 healthy (24 Japanese and 24 Caucasian subjects), nonsmoking male volunteers who were equally… read more here.

Keywords: ataluren pharmacokinetics; pharmacology; japanese caucasian; healthy japanese ... See more keywords