Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
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DOI: 10.1158/1535-7163.mct-18-1394
Abstract: AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated (ATM) protein, a signaling kinase involved in the DNA damage response. We present preclinical data demonstrating abrogation of irradiation-induced ATM signaling by low doses… read more here.
Keywords: pharmacology atm; atm inhibitor; inhibitor azd0156; irradiation ... See more keywords