A predictive index of biomarkers for ictogenesis from tier I safety pharmacology testing that may warrant tier II EEG studies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2018.05.002
Abstract: Three significant contributions to the field of safety pharmacology were recently published detailing the use of electroencephalography (EEG) by telemetry in a critical role in the successful evaluation of a compound during drug development (1]… read more here.
Keywords: safety pharmacology; safety; tier safety; pharmacology testing ... See more keywords
Core battery safety pharmacology testing - An assessment of its utility in early drug development.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2021.107055
Abstract: Requirements for safety pharmacology testing have been in place since the issue of initial regulatory guidance over 20 years ago. An evaluation of such testing, supporting first clinical entry of 105 small molecule drug candidates over… read more here.
Keywords: safety pharmacology; core battery; drug; pharmacology testing ... See more keywords