Novel methods for the assessment of safety pharmacology and toxicology parameters in anesthetized and ventilated dogs receiving inhaled drugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.04.004
Abstract: INTRODUCTION For nonclinical drug development, it is optimal if safety pharmacology and toxicology studies are performed in a model that reasonably represents the patient the drug is intended to treat. To simulate prolonged inhalation therapy… read more here.
Keywords: ventilated dogs; safety pharmacology; pharmacology toxicology; pharmacology ... See more keywords
The National Gene Vector Biorepository. Eleven Years of Providing Resources to the Gene Therapy Community.
Sign Up to like & getrecommendations! Published in 2020 at "Human gene therapy"
DOI: 10.1089/hum.2019.317
Abstract: The NGVB program has been highly accessed by gene therapy investigators. The Reagent Repository has distributed over 1,000 reagents to 397 investigators. The Pharmacology/Toxicology Archive contains over 36,000 specimens from a variety of AAV, Adenoviral… read more here.
Keywords: national gene; pharmacology toxicology; gene therapy; gene ... See more keywords
Altered pharmacology and toxicology during ageing: implications for lung disease
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pulmonary Medicine"
DOI: 10.1097/mcp.0000000000000878
Abstract: Purpose of review Drug use in elderly people is high compared to younger people. Simultaneously, elderly are at greater risk when exposed to environmental substances. It is puzzling therefore, that ageing, as a variable in… read more here.
Keywords: pharmacology; toxicology; pharmacology toxicology; lung disease ... See more keywords
Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-051421-105617
Abstract: Pharmacology and toxicology are part of a much broader effort to understand the relationship between chemistry and biology. While biomedicine has necessarily focused on specific cases, typically of direct human relevance, there are real advantages… read more here.
Keywords: toxicology; systems pharmacology; pharmacology; pharmacology toxicology ... See more keywords
Introduction to the Theme "Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care".
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-091222-022612
Abstract: Investigations in pharmacology and toxicology range from molecular studies to clinical care. Studies in basic and clinical pharmacology and in preclinical and clinical toxicology are all essential in bringing new knowledge and new drugs into… read more here.
Keywords: new drugs; toxicology; pharmacology; pharmacology toxicology ... See more keywords