Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias
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DOI: 10.1371/journal.pone.0181830
Abstract: Pharmacoperones are small molecules that diffuse into cells and rescue misfolded, mistrafficked protein mutants, restoring their function. These substances act with high target specificity, serving as templates to fold (or refold) receptors, enzymes, ion channels… read more here.
Keywords: receptor mutants; pharmacoperone; constitutive activity; rescue ... See more keywords