Combined multi-pharmacophore, molecular docking and molecular dynamic study for discovery of promising MTH1 inhibitors
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DOI: 10.1016/j.molstruc.2017.02.034
Abstract: Abstract MutT homolog 1 (MTH1), a nudix phosphohydrolase enzyme participates in the process of repairing of DNA damage by hydrolyzing oxidized deoxy-ribonucleoside triphosphate in cancer cells, is regarded as a potential target for anticancer therapy.… read more here.
Keywords: promising mth1; pharmacophore molecular; multi pharmacophore; combined multi ... See more keywords
The Free Radical Scavenging Property of the Leaves, Branches, and Roots of Mansoa hirsuta DC: In Vitro Assessment, 3D Pharmacophore, and Molecular Docking Study
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DOI: 10.3390/molecules27186016
Abstract: In this work, a metabolic profile of Mansoa hirsuta was investigated, and in vitro assays and theoretical approaches were carried out to evaluate its antioxidant potential. The phytochemical screening detected saponins, organic acids, phenols, tannins,… read more here.
Keywords: molecular docking; mansoa hirsuta; branches roots; leaves branches ... See more keywords