1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1748026
Abstract: Abstract There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During… read more here.
Keywords: epilepsy; pharmacoresistant epilepsy; ros scavenging; model pharmacoresistant ... See more keywords
The Pharmacoresistant Epilepsy: An Overview on Existant and New Emerging Therapies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.674483
Abstract: Epilepsy is one of the most common neurological chronic disorders, with an estimated prevalence of 0. 5 – 1%. Currently, treatment options for epilepsy are predominantly based on the administration of symptomatic therapy. Most patients… read more here.
Keywords: pharmacoresistant epilepsy; existant new; epilepsy overview; overview existant ... See more keywords