Novel phenyl and thiophene dispiro indenoquinoxaline pyrrolidine quinolones induced apoptosis via G1/S and G2/M phase cell cycle arrest in MCF-7 cells
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DOI: 10.1039/d0nj02588g
Abstract: New phenyl and thiophene dispiro indeno quinoxaline pyrrolidine quinolone analogues were synthesized by a one-pot four-component [3+2] cycloaddition reaction between (E)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones, o-phenylenediamine, ninhydrin, and benzylamine/thiophenemethylamine. The structure and regio- and stereochemistry of the compounds have… read more here.
Keywords: phenyl thiophene; mcf cells; phase cell; thiophene dispiro ... See more keywords
RAD51 Inhibition Induces R-Loop Formation in Early G1 Phase of the Cell Cycle
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DOI: 10.3390/ijms22073740
Abstract: R-loops are three-stranded structures generated by annealing of nascent transcripts to the template DNA strand, leaving the non-template DNA strand exposed as a single-stranded loop. Although R-loops play important roles in physiological processes such as… read more here.
Keywords: loop formation; phase cell; rad51 inhibition; early phase ... See more keywords
Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes
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DOI: 10.3390/ijms23116290
Abstract: Chemotherapy-induced thrombocytopenia (CIT) is a common complication when treating malignancies with cytotoxic agents wherein carboplatin is one of the most typical agents causing CIT. Janus kinase 2 (JAK2) is one of the critical enzymes to… read more here.
Keywords: cell; cell cycle; carboplatin induced; induced thrombocytopenia ... See more keywords