A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.01.012
Abstract: The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of… read more here.
Keywords: drug metabolizing; phase drug; physiological concentration; metabolizing enzymes ... See more keywords
Phase 3 drug pipelines in the treatment of non‐alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology Research"
DOI: 10.1111/hepr.13425
Abstract: Non‐alcoholic steatohepatitis (NASH), which is a more severe form of non‐alcoholic fatty liver disease, can at least partly lead to cirrhosis, hepatocellular carcinoma, and hepatic failure. Liver transplantation is the only option for NASH cirrhosis… read more here.
Keywords: phase drug; non alcoholic; alcoholic steatohepatitis; drug ... See more keywords
Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release
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DOI: 10.3390/polym14112132
Abstract: One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid… read more here.
Keywords: layer; phase drug; dual phase; release ... See more keywords