Untargeted screening of phase I metabolism of combretastatin A4 by multi-tool analysis.
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DOI: 10.1016/j.talanta.2018.01.051
Abstract: The aim of the current study was to apply different strategies for generation of metabolites of combretastatin A4 (CA4) and subsequent identification of the unknown products of phase I metabolism. CA4 is a potent anti-tubulin… read more here.
Keywords: screening phase; metabolism; multi tool; phase metabolism ... See more keywords
The Effect of Piperine Pro-Nano Lipospheres on Direct Intestinal Phase II Metabolism: The Raloxifene Paradigm of Enhanced Oral Bioavailability.
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DOI: 10.1021/acs.molpharmaceut.7b01090
Abstract: Phase II biotransformation reactions have been gaining more attention due to their acknowledged significance in drug bioavailability, drug development, and drug-drug interactions. However, the predominant role of phase I metabolism has always overshadowed phase II metabolism, resulting… read more here.
Keywords: effect; nano lipospheres; phase metabolism; raloxifene ... See more keywords