Simultaneous determination of carbamazepine-N-glucuronide and carbamazepine phase I metabolites in the wastewater by liquid chromatography-tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Microchemical Journal"
DOI: 10.1016/j.microc.2018.12.014
Abstract: Abstract Carbamazepine (CBZ) is one of the most frequently detected pharmaceuticals in the aquatic environment. In the human body, CBZ is metabolized and transformed into a variety of metabolites. Among metabolites, CBZ N-glucuronide (CBZ-Glu, Phase… read more here.
Keywords: phase metabolites; cbz; carbamazepine; cbz glu ... See more keywords
A novel strategy for the characterization of glaucocalyxin A metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on DDA and DIA data acquisitions
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DOI: 10.1039/c9ra06830a
Abstract: Glaucocalyxin A (GLA) belongs to the natural ent-kauranoid diterpenoids family with antitumor, antifibrotic, anticoagulative, antioxidant, and anti-AD effects. In this study, ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) system was applied to… read more here.
Keywords: dia; uhplc tof; glaucocalyxin; phase metabolites ... See more keywords
Profiling of in vivo, in vitro and reactive zorifertinib metabolites using liquid chromatography ion trap mass spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02848d
Abstract: Zorifertinib (AZD-3759; ZFB) is a potent, novel, oral, small molecule used for the treatment of non-small cell lung cancer (NSCLC). ZFB is Epidermal Growth Factor Receptor (EGFR) inhibitor that is characterized by good permeability of… read more here.
Keywords: phase; phase metabolites; vivo phase; zorifertinib ... See more keywords
Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
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DOI: 10.1080/00498254.2016.1204567
Abstract: Abstract 1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously.… read more here.
Keywords: daphnetin; daphnetin phase; catechol methyltransferase; comt ... See more keywords
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
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DOI: 10.1080/00498254.2021.1961920
Abstract: Abstract Podophyllotoxin (POD) is a natural compound with antiviral and anticancer activities. The purpose of the present study was to determine the metabolic map of POD in vitro and in vivo. Mouse and human liver… read more here.
Keywords: podophyllotoxin; drug; map antiviral; pod ... See more keywords
Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats
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DOI: 10.3389/fphar.2020.594852
Abstract: Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects. However, as for berberine’s metabolites,… read more here.
Keywords: excretion berberine; berberine nine; nine metabolites; pharmacokinetics excretion ... See more keywords
Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models
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DOI: 10.3389/fphar.2021.655332
Abstract: The clinical use of Polygonum multiflorum Thunb (PM) has been restricted or banned in many countries, due to its hepatotoxic adverse effects. Its toxicity research has become a hot topic. So far, the pharmacokinetic studies… read more here.
Keywords: multiflorum thunb; phase metabolites; phase; polygonum multiflorum ... See more keywords
Identification of D-Limonene Metabolites by LC-HRMS: An Exploratory Metabolic Switching Approach in a Mouse Model of Diet-Induced Obesity
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DOI: 10.3390/metabo12121246
Abstract: Metabolic switching has been raised as an important phenomenon to be studied in relation to xenobiotic metabolites, since the dose of the exposure determines the formation of metabolites and their bioactivity. Limonene is a monoterpene… read more here.
Keywords: phase metabolites; limonene; diet induced; metabolic switching ... See more keywords