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   Articles with "phase metabolites" as a keyword



Methylation of phase II metabolites of endogenous anabolic androgenic steroids to improve analytical performance

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recommendations! Published in 2024 at "Drug Testing and Analysis"

DOI: 10.1002/dta.3694

Abstract: Abstract The study of intact phase II metabolites of endogenous anabolic androgenic steroids (EAAS) gives important information about metabolism and has the potential to improve the detection of doping with testosterone. For analysis with liquid… read more here.

Keywords: methylation; phase metabolites; endogenous anabolic; metabolites endogenous ... See more keywords

Metabolism of highly potent synthetic opioid nitazene analogs: N-ethyl-N-(1-glucuronyloxyethyl) metabolite formation and degradation to N-desethyl metabolites during enzymatic hydrolysis.

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recommendations! Published in 2024 at "Drug testing and analysis"

DOI: 10.1002/dta.3705

Abstract: The metabolism of the highly potent synthetic opioids metonitazene, etonitazene, and protonitazene was investigated in fresh human hepatocytes. In the hydrolyzed culture medium, N-desethyl-, N,N-di-desethyl-, O-desalkyl-, N-desethyl-O-desalkyl-, N,N-di-desethyl-O-desalkyl-, and N-oxidated metabolites were detected as phase… read more here.

Keywords: metabolism highly; desethyl; phase metabolites; ethyl glucuronyloxyethyl ... See more keywords

Simultaneous determination of carbamazepine-N-glucuronide and carbamazepine phase I metabolites in the wastewater by liquid chromatography-tandem mass spectrometry

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recommendations! Published in 2019 at "Microchemical Journal"

DOI: 10.1016/j.microc.2018.12.014

Abstract: Abstract Carbamazepine (CBZ) is one of the most frequently detected pharmaceuticals in the aquatic environment. In the human body, CBZ is metabolized and transformed into a variety of metabolites. Among metabolites, CBZ N-glucuronide (CBZ-Glu, Phase… read more here.

Keywords: phase metabolites; cbz; carbamazepine; cbz glu ... See more keywords
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A novel strategy for the characterization of glaucocalyxin A metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on DDA and DIA data acquisitions

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recommendations! Published in 2020 at "RSC Advances"

DOI: 10.1039/c9ra06830a

Abstract: Glaucocalyxin A (GLA) belongs to the natural ent-kauranoid diterpenoids family with antitumor, antifibrotic, anticoagulative, antioxidant, and anti-AD effects. In this study, ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) system was applied to… read more here.

Keywords: dia; uhplc tof; glaucocalyxin; phase metabolites ... See more keywords

Profiling of in vivo, in vitro and reactive zorifertinib metabolites using liquid chromatography ion trap mass spectrometry

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recommendations! Published in 2022 at "RSC Advances"

DOI: 10.1039/d2ra02848d

Abstract: Zorifertinib (AZD-3759; ZFB) is a potent, novel, oral, small molecule used for the treatment of non-small cell lung cancer (NSCLC). ZFB is Epidermal Growth Factor Receptor (EGFR) inhibitor that is characterized by good permeability of… read more here.

Keywords: phase; phase metabolites; vivo phase; zorifertinib ... See more keywords

Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites

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recommendations! Published in 2017 at "Xenobiotica"

DOI: 10.1080/00498254.2016.1204567

Abstract: Abstract 1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously.… read more here.

Keywords: daphnetin; daphnetin phase; catechol methyltransferase; comt ... See more keywords
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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity

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recommendations! Published in 2021 at "Xenobiotica"

DOI: 10.1080/00498254.2021.1961920

Abstract: Abstract Podophyllotoxin (POD) is a natural compound with antiviral and anticancer activities. The purpose of the present study was to determine the metabolic map of POD in vitro and in vivo. Mouse and human liver… read more here.

Keywords: podophyllotoxin; drug; map antiviral; pod ... See more keywords
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Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

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recommendations! Published in 2020 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2020.594852

Abstract: Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects. However, as for berberine’s metabolites,… read more here.

Keywords: excretion berberine; berberine nine; nine metabolites; pharmacokinetics excretion ... See more keywords

Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models

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recommendations! Published in 2021 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2021.655332

Abstract: The clinical use of Polygonum multiflorum Thunb (PM) has been restricted or banned in many countries, due to its hepatotoxic adverse effects. Its toxicity research has become a hot topic. So far, the pharmacokinetic studies… read more here.

Keywords: multiflorum thunb; phase metabolites; phase; polygonum multiflorum ... See more keywords

Identification of D-Limonene Metabolites by LC-HRMS: An Exploratory Metabolic Switching Approach in a Mouse Model of Diet-Induced Obesity

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recommendations! Published in 2022 at "Metabolites"

DOI: 10.3390/metabo12121246

Abstract: Metabolic switching has been raised as an important phenomenon to be studied in relation to xenobiotic metabolites, since the dose of the exposure determines the formation of metabolites and their bioactivity. Limonene is a monoterpene… read more here.

Keywords: phase metabolites; limonene; diet induced; metabolic switching ... See more keywords