Novel Aryl Boronate Ester Based Amino Acids as Orthogonal Building Blocks for Fmoc Solid Phase Peptide Synthesis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201701064
Abstract: Three novel aryl boronate ester based amino acids are described. These useful building blocks were found to exhibit all of the chemical properties compatible to the Fmoc strategy solid-phase peptide synthesis and orthogonal to Boc,… read more here.
Keywords: novel aryl; solid phase; peptide synthesis; phase peptide ... See more keywords
Tetrahydropyranyl: A Non‐aromatic, Mild‐Acid‐Labile Group for Hydroxyl Protection in Solid‐Phase Peptide Synthesis
Sign Up to like & getrecommendations! Published in 2017 at "ChemistryOpen"
DOI: 10.1002/open.201600157
Abstract: Abstract The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side‐chain hydroxyl groups in solid‐phase peptide synthesis has not been widely investigated. Ser/Thr side‐chain hydroxyl protection with this acid‐labile and… read more here.
Keywords: protection; hydroxyl; group; solid phase ... See more keywords
Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0227-0_16
Abstract: Cell-penetrating peptides (CPPs) are relatively short peptides that can enter to the cell interior and facilitate intracellular delivery of associated cargo molecules. NickFects is a novel family of CPPs, designed to deliver various types of… read more here.
Keywords: solid phase; peptide synthesis; phase peptide; family cpps ... See more keywords
Fmoc Solid Phase Peptide Synthesis of Oxytocin and Analogues.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1759-5_11
Abstract: Solid phase peptide synthesis is the most commonly used method for the production of peptides. In this chapter, we outline the standard operating procedures used in our laboratory to efficiently access oxytocin-like peptides. This includes detailed… read more here.
Keywords: phase peptide; fmoc solid; solid phase; peptide synthesis ... See more keywords
A facile method for monitoring solid-phase peptide synthesis and for N-terminal modification of peptides: synthesis of short peptides for imaging specific cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-019-1683-9
Abstract: A simple method for naked-eye detection of free amine groups during solid-phase peptide synthesis is reported. The technique involves base-catalyzed cyclization of 2-(2-oxo-2H-acenaphthylene-1-ylidene)-malononitrile (1) and subsequent oxidative substitution of aryl moiety by free amine group… read more here.
Keywords: terminal modification; solid phase; peptide synthesis; phase peptide ... See more keywords
Direct solid-phase peptide synthesis on chitosan microparticles for targeting tumor cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.101288
Abstract: Abstract An EGFR-targeting peptide with Ala-Glu-Tyr-Leu-Arg sequence was assembled directly onto the surface of spray-dried chitosan microparticles using solid-phase peptide synthesis with Fmoc chemistry. Both targeted and scrambled peptides were cleaved from chitosan with enzymatic… read more here.
Keywords: chitosan microparticles; phase; solid phase; peptide synthesis ... See more keywords
Phenylglycine racemization in Fmoc-based solid-phase peptide synthesis: Stereochemical stability is achieved by choice of reaction conditions
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.04.047
Abstract: Abstract Phenylglycine-containing peptides have broad applications in medicinal chemistry, but their synthetic accessibility is complicated by the risk of epimerization during solid-phase peptide synthesis (SPPS). Phenylglycine is therefore often considered a troublesome residue. This work… read more here.
Keywords: racemization; solid phase; peptide synthesis; phase peptide ... See more keywords
Environmentally Sensible Organocatalytic Fmoc/t-Bu Solid-Phase Peptide Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00266
Abstract: Despite numerous reports on catalytic amide bond formation (ABF), these methods have thus far had a minimal impact on the universal fluorenylmethoxycarbonyl (Fmoc)/t-Bu solid-phase peptide synthesis (SPPS) methodology. We now report a proof-of-principle Fmoc/t-Bu SPPS… read more here.
Keywords: fmoc; synthesis; peptide synthesis; fmoc solid ... See more keywords
Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c04059
Abstract: α-Formylglycine (fGly) is a rare residue located in the active site of sulfatases and serves as a precursor to pharmaceutically relevant motifs. The installation of fGly motifs into peptides is currently challenging due to degradation… read more here.
Keywords: synthesis; peptide synthesis; solid phase; formylglycine building ... See more keywords
An optimised approach for continuous-flow solid-phase peptide synthesis utilising a rudimentary flow reactor
Sign Up to like & getrecommendations! Published in 2018 at "Reaction Chemistry and Engineering"
DOI: 10.1039/c8re00190a
Abstract: From the repurposing of used HPLC components, a chromatography column, a Rheodyne,® and a heater stirrer, a simple, cost-effective system to conveniently conduct continuous flow solid-phase peptide construction was assembled. Through the utilisation of this… read more here.
Keywords: solid phase; phase peptide; flow solid; continuous flow ... See more keywords
Amino-Li-Resin—A Fiber Polyacrylamide Resin for Solid-Phase Peptide Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14050928
Abstract: Amino-Li-resin is a new and unique polyacrylamide resin presented in the form of fibers and is found to be well suited for solid-phase peptide chemistry. Although amino-Li-resin swells much better in polar solvents, it is… read more here.
Keywords: solid phase; phase peptide; amino resin; resin ... See more keywords