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   Articles with "phase randomised" as a keyword



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A multicentre, open-label, phase-I/randomised phase-II study to evaluate safety, pharmacokinetics, and efficacy of nintedanib vs. sorafenib in European patients with advanced hepatocellular carcinoma

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recommendations! Published in 2018 at "British Journal of Cancer"

DOI: 10.1038/s41416-018-0051-8

Abstract: BackgroundThis multicentre, open-label, phase-I/randomised phase-II trial evaluated safety, pharmacokinetics, maximum-tolerated-dose (MTD) per dose-limiting toxicities (DLTs), and efficacy of nintedanib vs. sorafenib in European patients with unresectable advanced hepatocellular carcinoma (aHCC).MethodsPhase I: Patients were stratified into… read more here.

Keywords: open label; phase; phase randomised; label phase ... See more keywords
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Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials

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recommendations! Published in 2023 at "Cephalalgia"

DOI: 10.1177/03331024231159366

Abstract: Background Several novel treatments targeting the calcitonin gene-related peptide pathway have been developed for migraine. We evaluated the efficacy of these medications, including atogepant, rimegepant, erenumab, eptinezumab, fremanezumab, and galcanezumab, for the prevention of migraine… read more here.

Keywords: meta analysis; phase randomised; migraine; controlled trials ... See more keywords
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METRO-BIBF: Phase II, randomised, placebo controlled, multicentre, trial of low dose (metronomic) cyclophosphamide (MCy) with or without nintedanib in relapsed ovarian cancer (ROC).

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recommendations! Published in 2018 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2018.36.15_suppl.5551

Abstract: 5551Background: ROC patients (pts), heavily pretreated with IV chemotherapy (CT) are a heterogenous group, median OS 3-9 mo. Oral MCy is well tolerated, avoids IV CT and has been shown to have clin... read more here.

Keywords: phase randomised; metro bibf; roc; randomised placebo ... See more keywords