Incidence of Primary End Point Changes Among Active Cancer Phase 3 Randomized Clinical Trials
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.13819
Abstract: This cross-sectional study assesses the frequency of reporting of primary end point changes among active oncology phase 3 randomized clinical trials. read more here.
Keywords: among active; end point; point changes; primary end ... See more keywords
Efficacy of Endocrine Therapy for the Treatment of Breast Cancer in Men: Results from the MALE Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2020.7442
Abstract: Importance The extent of changes in estradiol levels in male patients with hormone receptor-positive breast cancer receiving standard endocrine therapies is unknown. The sexual function and quality of life related to those changes have not… read more here.
Keywords: clinical trial; trial; estradiol levels; randomized clinical ... See more keywords
Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7364
Abstract: This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma. read more here.
Keywords: clinical trials; systematic review; randomized clinical; phase randomized ... See more keywords
A phase 1 and randomized, placebo‐controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32340
Abstract: Src signaling is markedly upregulated in patients with invasive glioblastoma (GBM) after the administration of bevacizumab. The Src family kinase inhibitor dasatinib has been found to effectively block bevacizumab‐induced glioma invasion in preclinical models, which… read more here.
Keywords: bevacizumab; placebo controlled; randomized placebo; phase randomized ... See more keywords
A Phase 1, Randomized, Placebo‐Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Subcutaneous Tezepelumab in Healthy Japanese Men
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.775
Abstract: Tezepelumab, a human immunoglobulin G2 monoclonal antibody against thymic stromal lymphopoietin, is currently under clinical development for the treatment of severe, uncontrolled asthma. This phase 1, randomized, placebo‐controlled, single‐ascending‐dose study assessed the safety, tolerability, pharmacokinetics,… read more here.
Keywords: placebo; safety; phase randomized; healthy japanese ... See more keywords
A PHASE 2B RANDOMIZED STUDY OF SINGLE AGENT SELINEXOR IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL)
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DOI: 10.1002/hon.2438_53
Abstract: high‐dose steroids. All patients have efficacy reassessment after RLI window with an ORR of 82% and CR rate of 42%. The 6 patients who have completed all therapy have all achieved a CR. Conclusions: The… read more here.
Keywords: single agent; study single; randomized study; study ... See more keywords
Phase I Randomized Trial of 17O‐Labeled Water: Safety and Feasibility Study of Indirect Proton MRI for the Evaluation of Cerebral Water Dynamics
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DOI: 10.1002/jmri.28210
Abstract: 17O‐labeled water (PSO17) is a contrast agent developed to measure brain water dynamics and cerebral blood flow. read more here.
Keywords: labeled water; water; 17o labeled; randomized trial ... See more keywords
Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study
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DOI: 10.1007/s10157-021-02047-2
Abstract: The pathophysiology of uremic pruritus (UP), which is characterized by systemic and intractable itching, remains unclear. As interleukin (IL)-31 may be involved, we conducted a phase II, randomized, controlled study to evaluate nemolizumab (anti-IL-31 receptor… read more here.
Keywords: phase; study; uremic pruritus; phase randomized ... See more keywords
OnabotulinumtoxinA for the treatment of major depressive disorder: a phase 2 randomized, double-blind, placebo-controlled trial in adult females
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DOI: 10.1097/yic.0000000000000290
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: depressive disorder; major depressive; onabotulinumtoxina treatment; phase randomized ... See more keywords
A phase 1b randomized, placebo‐controlled clinical trial with SNF472 in haemodialysis patients
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DOI: 10.1111/bcp.13863
Abstract: SNF472 is a calcification inhibitor that is being studied as a novel treatment for calciphylaxis and cardiovascular calcification (CVC). A first study showed acceptable safety and tolerability in a single ascending dose administration in healthy… read more here.
Keywords: haemodialysis patients; trial; haemodialysis; phase randomized ... See more keywords
Efficacy of keverprazan for duodenal ulcer: A phase II randomized, double‐blind, parallel‐controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16000
Abstract: Considering the limitation of varying acid suppression of proton pump inhibitors, this study was aimed to assess the efficacy, safety, and dose–effect relationship of keverprazan, a novel potassium‐competitive acid blocker, in the treatment of duodenal… read more here.
Keywords: duodenal ulcer; efficacy keverprazan; efficacy; phase randomized ... See more keywords