Ivarmacitinib for Moderate to Severe Atopic Dermatitis in Adults and Adolescents: A Phase 3 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2025.0982
Abstract: Importance Ivarmacitinib, a selective oral Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy for treating adults with moderate to severe atopic dermatitis (AD) in a phase 2 trial. Objective To evaluate the efficacy and adverse… read more here.
Keywords: moderate severe; ivarmacitinib; trial; group ... See more keywords
Incidence of Primary End Point Changes Among Active Cancer Phase 3 Randomized Clinical Trials
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.13819
Abstract: This cross-sectional study assesses the frequency of reporting of primary end point changes among active oncology phase 3 randomized clinical trials. read more here.
Keywords: among active; end point; point changes; primary end ... See more keywords
Efficacy of Endocrine Therapy for the Treatment of Breast Cancer in Men: Results from the MALE Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2020.7442
Abstract: Importance The extent of changes in estradiol levels in male patients with hormone receptor-positive breast cancer receiving standard endocrine therapies is unknown. The sexual function and quality of life related to those changes have not… read more here.
Keywords: clinical trial; trial; estradiol levels; randomized clinical ... See more keywords
Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7364
Abstract: This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma. read more here.
Keywords: clinical trials; systematic review; randomized clinical; phase randomized ... See more keywords
Stereotactic Body Radiotherapy vs Sorafenib Alone in Hepatocellular Carcinoma: The NRG Oncology/RTOG 1112 Phase 3 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.5403
Abstract: Importance Most patients with locally advanced hepatocellular carcinoma (HCC) recur within the liver following systemic therapy. Objective To determine whether stereotactic body radiation therapy (SBRT) improves outcomes in patients with locally advanced HCC compared with… read more here.
Keywords: oncology; trial; sorafenib alone; sbrt ... See more keywords
A phase 1 and randomized, placebo‐controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32340
Abstract: Src signaling is markedly upregulated in patients with invasive glioblastoma (GBM) after the administration of bevacizumab. The Src family kinase inhibitor dasatinib has been found to effectively block bevacizumab‐induced glioma invasion in preclinical models, which… read more here.
Keywords: bevacizumab; placebo controlled; randomized placebo; phase randomized ... See more keywords
A Phase 1, Randomized, Placebo‐Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Subcutaneous Tezepelumab in Healthy Japanese Men
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.775
Abstract: Tezepelumab, a human immunoglobulin G2 monoclonal antibody against thymic stromal lymphopoietin, is currently under clinical development for the treatment of severe, uncontrolled asthma. This phase 1, randomized, placebo‐controlled, single‐ascending‐dose study assessed the safety, tolerability, pharmacokinetics,… read more here.
Keywords: placebo; safety; phase randomized; healthy japanese ... See more keywords
CB1 Receptor Antagonist Selonabant (ANEB‐001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3581
Abstract: Emergency department visits due to cannabinoid‐induced toxicity, including acute cannabinoid intoxication (ACI) have increased worldwide as more states have liberalized cannabis policy. ACI symptoms include anxiety, panic attacks, tachycardia, and psychosis, primarily mediated through cannabinoid… read more here.
Keywords: receptor; cb1 receptor; thc; receptor antagonist ... See more keywords
A PHASE 2B RANDOMIZED STUDY OF SINGLE AGENT SELINEXOR IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL)
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_53
Abstract: high‐dose steroids. All patients have efficacy reassessment after RLI window with an ORR of 82% and CR rate of 42%. The 6 patients who have completed all therapy have all achieved a CR. Conclusions: The… read more here.
Keywords: single agent; study single; randomized study; study ... See more keywords
Phase 1 randomized pharmacokinetic and safety study of a 90‐day tenofovir vaginal ring in the United States
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.26223
Abstract: Tenofovir‐based oral pre‐exposure prophylaxis is currently approved for HIV prevention; however, adherence in women has been low. A vaginal gel containing tenofovir (TFV) demonstrated partial protection to HIV but protection was not confirmed in additional… read more here.
Keywords: safety study; randomized pharmacokinetic; safety; phase randomized ... See more keywords
Phase I Randomized Trial of 17O‐Labeled Water: Safety and Feasibility Study of Indirect Proton MRI for the Evaluation of Cerebral Water Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28210
Abstract: 17O‐labeled water (PSO17) is a contrast agent developed to measure brain water dynamics and cerebral blood flow. read more here.
Keywords: labeled water; water; 17o labeled; randomized trial ... See more keywords