TRPC4/5 inhibitors: Phase I results and proof of concept studies
Sign Up to like & getrecommendations! Published in 2024 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-024-01890-0
Abstract: Transient receptor potential canonical (TRPC) ion channels are expressed in areas of the brain responsible for processing emotion and mood and have been implicated in the pathophysiology of internalizing disorders such as major depressive disorder… read more here.
Keywords: ion channels; inhibitors phase; trpc4 inhibitors; phase results ... See more keywords
PD03-02 PHASE 3 RESULTS OF VICINIUM IN BCG-UNRESPONSIVE NON-MUSCLE INVASIVE BLADDER CANCER
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000823.02
Abstract: INTRODUCTION AND OBJECTIVE:Alternatives to radical cystectomy (RC) are critically needed for the treatment of high-risk BCG-unresponsive NMIBC. Vicinium is a recombinant fusion protein comprised of... read more here.
Keywords: phase results; bcg unresponsive; results vicinium; vicinium bcg ... See more keywords
Pilot phase results of a prospective, randomized controlled trial of narrowband ultraviolet B phototherapy in hospitalized COVID‐19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14617
Abstract: COVID‐19 morbidity and mortality are driven by poor immune regulation. Narrowband ultraviolet B (NB‐UVB) phototherapy is standard of care in a number of immune‐dysregulated diseases. To assess the efficacy of NB‐UVB phototherapy for improving COVID‐19… read more here.
Keywords: narrowband ultraviolet; phase results; pilot phase; trial ... See more keywords
SARC037: Phase II results of trabectedin given as a 1-hour (h) infusion in combination with low dose irinotecan in patients (pts) with relapsed/refractory Ewing sarcoma (ES).
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.11508
Abstract: 11508 Background: Trabectedin(T) is a marine-derived minor groove DNA binding compound that alters transcription factor activity. Preclinical data suggests that T suppresses the oncogenic driver of ES, EWS::FLI1. This suppression requires a threshold concentration of… read more here.
Keywords: pts relapsed; relapsed refractory; infusion; phase results ... See more keywords