Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study
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DOI: 10.1002/acn3.51254
Abstract: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease caused by deficient activity of arylsulfatase A (ASA), resulting in severe motor and cognitive dysfunction. This phase 1/2 study evaluated the safety and efficacy of… read more here.
Keywords: metachromatic leukodystrophy; phase study; arylsulfatase;
A phase 1 study of AMG 900, an orally administered pan‐aurora kinase inhibitor, in adult patients with acute myeloid leukemia
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DOI: 10.1002/ajh.24736
Abstract: Aurora kinases are involved in the pathophysiology of several cancers including acute myeloid leukemia (AML). In this phase 1 study, we investigated the safety and efficacy of AMG 900, an orally administered, highly potent, selective,… read more here.
Keywords: myeloid leukemia; amg 900; acute myeloid; phase study ... See more keywords
Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high‐risk MDS: Phase 2 study results
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DOI: 10.1002/ajh.25238
Abstract: Glasdegib is a Hedgehog pathway inhibitor. This ongoing, open‐label, phase 2 study (NCT01546038) evaluated glasdegib plus cytarabine/daunorubicin in patients with untreated acute myeloid leukemia (AML) or high‐risk myelodysplastic syndromes (MDS). Patients received glasdegib 100 mg… read more here.
Keywords: cytarabine daunorubicin; high risk; aml high; phase study ... See more keywords
A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes
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DOI: 10.1002/ajh.26771
Abstract: Patients with relapsed/refractory (R/R) higher‐risk myelodysplastic syndromes (MDS) have a dismal median overall survival (OS) after failing hypomethylating agent (HMA) treatment. There is no standard of care for patients after HMA therapy failure; hence, there… read more here.
Keywords: myelodysplastic syndromes; relapsed refractory; venetoclax azacitidine; phase study ... See more keywords
Levetiracetam as a sensitizer of concurrent chemoradiotherapy in newly diagnosed glioblastoma: An open‐label phase 2 study
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DOI: 10.1002/cam4.4454
Abstract: An open‐label single‐arm phase 2 study was conducted to evaluate the role of levetiracetam as a sensitizer of concurrent chemoradiotherapy (CCRT) for patients with newly diagnosed glioblastoma. This study aimed to determine the survival benefit… read more here.
Keywords: study; levetiracetam sensitizer; glioblastoma; sensitizer concurrent ... See more keywords
Phase I study of adjuvant chemotherapy with nab‐paclitaxel and S‐1 for stage III Lauren's diffuse‐type gastric cancer after D2 resection (NORDICA study)
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DOI: 10.1002/cam4.4966
Abstract: The prognosis of diffuse‐type gastric cancer (DGC) is poorer than that of intestinal type, but S‐1 is a potential treatment option in DGC. This study explored the maximal tolerated dose (MTD) and the recommended dose… read more here.
Keywords: type gastric; diffuse type; gastric cancer; phase study ... See more keywords
Randomized phase II study of capecitabine plus cisplatin with or without sorafenib in patients with metastatic gastric cancer (STARGATE)
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DOI: 10.1002/cam4.5536
Abstract: In this randomized phase II study, we evaluated the efficacy and safety of sorafenib in combination with capecitabine and cisplatin (XP) as first‐line chemotherapy in advanced gastric cancer. read more here.
Keywords: gastric cancer; randomized phase; cancer; phase study ... See more keywords
BL‐8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open‐label safety and efficacy phase 2a study
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DOI: 10.1002/cncr.33338
Abstract: CXCR4 mediates the retention and survival of acute myelogenous leukemia blasts in bone marrow and contributes to their resistance to chemotherapy. The authors evaluated a combination of the high‐affinity CXCR4 antagonist BL‐8040 with high‐dose cytarabine… read more here.
Keywords: relapsed refractory; cxcr4 antagonist; myelogenous leukemia; phase study ... See more keywords
Olmutinib in T790M‐positive non–small cell lung cancer after failure of first‐line epidermal growth factor receptor‐tyrosine kinase inhibitor therapy: A global, phase 2 study
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DOI: 10.1002/cncr.33385
Abstract: In this open‐label, international phase 2 study, the authors assessed the efficacy and safety of olmutinib in patients with locally advanced or metastatic non–small cell lung cancer (NSCLC) who had a confirmed T790M mutation and… read more here.
Keywords: lung cancer; cell lung; non small; cancer ... See more keywords
A phase 2 study of sorafenib combined with conventional therapies in refractory central nervous system leukemia
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DOI: 10.1002/cncr.34182
Abstract: Patients with refractory central nervous system leukemia (CNSL) have a dismal prognosis and lack effective therapy. Case reports have shown that sorafenib is effective against brain metastases, including leukemia. read more here.
Keywords: system leukemia; central nervous; refractory central; phase study ... See more keywords
OER‐073: A multicenter phase 2 study evaluating the role of pazopanib in angiosarcoma
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DOI: 10.1002/cncr.34403
Abstract: Angiosarcomas are rare mesenchymal sarcomas that can present as primary cutaneous or noncutaneous disease. They express a variety of vascular endothelial growth factor receptors. The authors hypothesized that the treatment of angiosarcoma with pazopanib, a… read more here.
Keywords: oer 073; pazopanib; 073 multicenter; multicenter phase ... See more keywords