Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS
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DOI: 10.1007/s00018-021-03792-z
Abstract: Transactive response DNA-binding protein 43 kDa (TDP-43) encoded by the TARDBP gene is an evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that regulates multiple steps of RNA metabolism, and its cytoplasmic aggregation characterizes degenerating motor neurons… read more here.
Keywords: multi phaseted; vulnerability als; motor neurons; vulnerability ... See more keywords